SCHVARTZMAN, Clémence; IBARBOURE, Emmanuel; MARTIN, Anouk; GARANGER, Elisabeth; MUTSCHLER, Angela; LECOMMANDOUX, Sébastien

doi:10.1021/acs.biomac.4c00200

SCHVARTZMAN, Clémence
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

IBARBOURE, Emmanuel
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

MARTIN, Anouk

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Biomacromolecules. 2024-06-03

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Living cells, especially eukaryotic ones, use multicompartmentalization to regulate intra- and extracellular activities, featuring membrane-bound and membraneless organelles. These structures govern numerous biological and chemical processes spatially and temporally. Synthetic cell models, primarily utilizing lipidic and polymeric vesicles, have been developed to carry out cascade reactions within their compartments. However, these reconstructions often segregate membrane-bound and membraneless organelles, neglecting their collaborative role in cellular regulation. To address this, we propose a structural design incorporating microfluidic-produced liposomes housing synthetic membrane-bound organelles made from self-assembled poly(ethylene glycol)--poly(trimethylene carbonate) nanovesicles and synthetic membraneless organelles formed via temperature-sensitive elastin-like polypeptide phase separation. This architecture mirrors natural cellular organization, facilitating a detailed examination of the interactions for a comprehensive understanding of cellular dynamics.< Leer menos

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https://oskar-bordeaux.fr/handle/20.500.12278/201177

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http://dx.doi.org/10.1021/acs.biomac.4c00200

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Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Protocells Featuring Membrane-Bound and Dynamic Membraneless Organelles.

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