LEVÊQUE, Manon; LECOMMANDOUX, Sébastien; GARANGER, Elisabeth

doi:10.1021/acs.biomac.4c00137

LEVÊQUE, Manon
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

LECOMMANDOUX, Sébastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

GARANGER, Elisabeth

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Biomacromolecules. 2024-05-13, vol. 25, n° 5, p. 3011-3017

Resumen en inglés

Stabilization against the dilution-dependent disassembly of self-assembled nanoparticles is a requirement for application. Herein, we propose a simple and biocompatible cross-linking reaction for the stabilization of a series of nanoparticles formed by the self-assembly of amphiphilic HA--ELP block copolymers, through the alkylation of methionine residues from the ELP block with diglycidyl ether compounds. The core-cross-linked nanoparticles retain their colloidal properties, with a spherical core-shell morphology, while maintaining thermoresponsive behavior. As such, instead of a reversible disassembly when non-cross-linked, a reversible swelling of nanoparticles' core and increase of hydrodynamic diameter are observed with lowering of the temperature.< Leer menos

Palabras clave en inglés

Nanoparticles

Cross-Linking Reagents

Temperature

Polymers

Elastin

Particle Size

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201176

DOI

http://dx.doi.org/10.1021/acs.biomac.4c00137

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Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Thermoresponsive Core-cross-linked Nanoparticles from HA--ELP Diblock Copolymers.

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Resumen en inglés

Palabras clave en inglés

URI

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Centros de investigación