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Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption

dc.rights.licenseopenen_US
dc.contributor.authorVIGNAULT, Adeline
dc.contributor.authorVAYSSE, Carole
dc.contributor.authorBERTAND, Karène
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorKRISA, Stephanie
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorCOURTOIS, Arnaud
IDREF: 092021301
dc.contributor.authorMORAS, Benjamin
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
dc.contributor.authorRICHARD, Tristan
dc.contributor.authorGAUDOUT, David
dc.contributor.authorPOURTAU, Line
dc.date.accessioned2024-07-11T08:17:00Z
dc.date.available2024-07-11T08:17:00Z
dc.date.issued2024-03-28
dc.identifier.issn2218-1989en_US
dc.identifier.urioai:crossref.org:10.3390/metabo14040190
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200841
dc.description.abstractEnThe therapeutic effects of saffron have been reported and described in relation to its major derivatives. Among them, in terms of saffron’s properties, crocin and crocetin absorption and bioavailability have been the most studied. Nevertheless, the metabolism of these major compounds of saffron has not yet been entirely elucidated. Current data indicate that the phase 2 metabolism of crocetins go through conjugation reactions. Crocetins could also be present in isomeric forms such as other carotenoids. Nonetheless, there are still shadow areas in regard to the measurements of the different circulating forms of crocetins after oral saffron extract administration (Safr’Inside™). In using various approaches, we propose the identification of a new cis isomeric form of crocetin, the 6-cis-crocetin. This compound was found in human serum samples after an oral administration of saffron extract. The 6-cis-crocetin represents 19% of the total crocetin measured after 45 min of consumption. These data mark, for the first time, the presence of a cis isomeric form of crocetin in human serum samples. Moreover, this study led to the development of an analytical method that is able to identify and quantify both isomeric forms (trans and cis).
dc.language.isoENen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcecrossref
dc.subject.enSaffron extract
dc.subject.enCrocin
dc.subject.enCrocetin
dc.subject.enIsomers
dc.subject.enMetabolism
dc.subject.enUHPLC-DAD-MS/MS
dc.subject.enNMR
dc.title.enCharacterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/metabo14040190en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
bordeaux.journalMetabolitesen_US
bordeaux.page190en_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesOenologie - UMR 1366en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04644567
hal.version1
hal.date.transferred2024-07-11T08:17:04Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Metabolites&rft.date=2024-03-28&rft.volume=14&rft.issue=4&rft.spage=190&rft.epage=190&rft.eissn=2218-1989&rft.issn=2218-1989&rft.au=VIGNAULT,%20Adeline&VAYSSE,%20Carole&BERTAND,%20Kar%C3%A8ne&KRISA,%20Stephanie&COURTOIS,%20Arnaud&rft.genre=article


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