MOISAND, Alexandra; MADERY, Mathilde; BOYER, Thomas; DOMBLIDES, Charlotte; BLAYE, Celine; LARMONIER, Nicolas

doi:10.3390/ijms242015048

MOISAND, Alexandra
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

MADERY, Mathilde
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

BOYER, Thomas
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

Langue

Article de revue

Ce document a été publié dans

International journal of molecular sciences. 2023-10, vol. 24, n° 20

Résumé en anglais

Breast cancers regroup many heterogeneous diseases unevenly responding to currently available therapies. Approximately 70–80% of breast cancers express hormone (estrogen or progesterone) receptors. Patients with these hormone-dependent breast malignancies benefit from therapies targeting endocrine pathways. Nevertheless, metastatic disease remains a major challenge despite available treatments, and relapses frequently ensue. By improving patient survival and quality of life, cancer immunotherapies have sparked considerable enthusiasm and hope in the last decade but have led to only limited success in breast cancers. In addition, only patients with hormone-independent breast cancers seem to benefit from these immune-based approaches. The present review examines and discusses the current literature related to the role of hormone receptor signaling (specifically, an estrogen receptor) and the impact of its modulation on the sensitivity of breast cancer cells to the effector mechanisms of anti-tumor immune responses and on the capability of breast cancers to escape from protective anti-cancer immunity. Future research prospects related to the possibility of promoting the efficacy of immune-based interventions using hormone therapy agents are considered. © 2023 by the authors.< Réduire

Mots clés en anglais

Hormone receptors

Estrogen receptors

Hormone signaling

Breast Cancer

Cancer immunity

Immunotherapies

URI

https://oskar-bordeaux.fr/handle/20.500.12278/200416

DOI

http://dx.doi.org/10.3390/ijms242015048

Project ANR

Ecole supérieure des jeunes chercheurs de l'Université de Bordeaux - ANR-20-SFRI-0001

Unités de recherche

ImmunoConcEpT - UMR 5164

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Hormone Receptor Signaling and Breast Cancer Resistance to Anti-Tumor Immunity