GOMBEAU, Kewin; DE OLIVEIRA, Ricardo Bezerra; SARRAZIN, Sandra Layse Ferreira; MOURÃO, Rosa Helena Veras; BOURDINEAUD, Jean-Paul

doi:10.5487/TR.2019.35.1.025

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GOMBEAU, Kewin
Environnements et Paléoenvironnements OCéaniques [EPOC]

DE OLIVEIRA, Ricardo Bezerra

SARRAZIN, Sandra Layse Ferreira

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Ce document a été publié dans

Toxicological Research. 2019-01-01, vol. 35, n° 1, p. 25-35

Résumé en anglais

The extracts of and are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast , and against mercurial contamination in zebrafish . In yeast, both extracts efficiently protected the Δ mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.< Réduire

Mots clés en anglais

Cadmium

Danio Rerio

Methylmercury

Oxidative Stress

Plant Extract

Saccharomyces Cerevisiae