SANSON, Charles; DIOU, Odile; THEVENOT, Julie; IBARBOURE, Emmanuel; SOUM, Alain; BRÛLET, Annie; MIRAUX, Sylvain; THIAUDIÈRE, Eric; TAN, Sisareuth; BRISSON, Alain; DUPUIS, Vincent; SANDRE, Olivier; LECOMMANDOUX, Sebastien

doi:10.1021/nn102762f

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SANSON, Charles
Laboratoire de Chimie des Polymères Organiques [LCPO]

DIOU, Odile
Laboratoire de Chimie des Polymères Organiques [LCPO]

THEVENOT, Julie
Laboratoire de Chimie des Polymères Organiques [LCPO]

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ACS Nano. 2011, vol. 5, n° 2, p. 1122-1140

American Chemical Society

Resumen en inglés

Hydrophobically modified maghemite (γ-Fe2O3) nanoparticles were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formation method gives a simple access to highly magnetic nanoparticles (MNPs) (loaded up to 70 wt %) together with a good control over the vesicles size (100 to 400 nm). The simultaneous loading of maghemite nanoparticles and doxorubicin was also achieved by nanoprecipitation. The deformation of the vesicle membrane under an applied magnetic field has been evidenced by small angle neutron scattering. These superparamagnetic hybrid self-assemblies display enhanced contrast properties that open potential applications for Magnetic Resonance Imaging. They can also be guided in a magnetic field gradient. The feasibility of controlled drug release by radio-frequency magnetic hyperthermia was demonstrated in the case of encapsulated doxorubicin molecules, showing the viability of the concept of magneto-chemotherapy. These magnetic polymersomes can be used as efficient multifunctional nano-carriers for combined therapy and imaging.< Leer menos

Palabras clave en inglés

block copolymer vesicles

polymersome

nanoprecipitation

superparamagnetic iron oxide nanoparticles

maghemite

magnetic hypethermia

magneto-chemotherapy

multifunctional

MRI contrast agent

doxorubicin

theranostics

URI

https://oskar-bordeaux.fr/handle/20.500.12278/20000

DOI

http://dx.doi.org/10.1021/nn102762f

Proyecto europeo

Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer

Orígen

Importado de Hal

Centros de investigación

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629