TUYEN DAO, T. P.; FERNANDES, Fabio; ER-RAFIK, Meriem; SALVA, Romain; SCHMUTZ, Marc; BRÛLET, Annie; PRIETO, Manuel; SANDRE, Olivier; LE MEINS, Jean-Francois

doi:10.1021/mz500748f

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Licence d’utilisation du document

TUYEN DAO, T. P.
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

FERNANDES, Fabio

ER-RAFIK, Meriem
Institut Charles Sadron [ICS]

Langue

Article de revue

Ce document a été publié dans

ACS Macro Letters. 2015, vol. 4, n° 2, p. 182-186

Washington, D.C : American Chemical Society

Résumé en anglais

Hybrid polymer/lipid large unilamellar vesicles (LUVS) were studied by small angle neutron scattering (SANS), time-resolved Forster resonance energy transfer (TR-FRET), and cryo-transmission electron microscopy (cryo-TEM). For the first time in hybrid vesicles, evidence for phase separation at the nanoscale was obtained, leading to the formation of stable nanodomains enriched either in lipid or polymer. This stability was allowed by using vesicle-forming copolymer with a membrane thickness dose to the lipid bilayer thickness, thereby minimizing the hydrophobic mismatch at the domain periphery. Hybrid giant unilamellar vesicles (GUVs) with the same composition have been previously shown to be unstable and susceptible to fission, suggesting a role of curvature in the stabilization of nanodomains in these structures.< Réduire

Mots clés en anglais

LIPID MEMBRANES

Fluorescence resonance energy transfer FRET

MEMBRANE COMPOSITION

LINE TENSION

RAFTS

NANODOMAINS

MICELLES

Hybrid membranes

LIPID-POLYMER BLENDS

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19991

DOI

http://dx.doi.org/10.1021/mz500748f

Project ANR

Cinétique de Translocation de Particules à travers de Bicouches Auto-Assemblées

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629