DEVILLIER, Philippe; MOLIMARD, Mathieu; BERGMANN, Jean-Francois; DELAISI, Bertrand; GOUVERNEUR, Amandine; VADEL, Jade; COLLIN, Cedric; GIRARD, Laurence; SCURATI, Silvia; DEMOLY, Pascal

doi:10.1080/1744666x.2023.2294040

Bordeaux population health [BPH]

BERGMANN, Jean-Francois

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Article de revue

Ce document a été publié dans

Expert Review of Clinical Immunology. 2023-12-19, vol. 20, n° 4, p. 405-412

Résumé en anglais

BACKGROUND: The only causal treatment for allergic rhinitis (AR) is allergen immunotherapy (AIT) including personalized liquid sublingual AIT (SLIT). We present the methodology for establishing the EfficAPSI cohort to further evaluate the real-life effectiveness and use of SLIT liquid. RESEARCH DESIGN AND METHODS: The EfficAPSI cohort was constituted by deterministic linkage of Stallergenes Greer dispensing and nationwide French healthcare insurance system (SNDS) databases. Data from 2006 to 2018 were extracted. All patients who initiated Stallergenes Greer SLIT liquid between 2010 and 2013 were considered as exposed and those dispensed with AR symptomatic treatment only as control. To limit the impact of confounding, the models will be weighted using the inverse probability of treatment weighting (IPTW). RESULTS: A total of 445,574 patients were included; median age was 38 years; 59.1% were female. Exposed patients (n = 112,492) were significantly younger, more frequently males, and less likely to have comorbidities than controls (n = 333,082). After IPTW, patients' characteristics from both groups were similar. CONCLUSIONS: To date, the EfficAPSI cohort has the largest number of person-years of follow-up in the field of AIT. The completeness of the data allows to evaluate SLIT liquid effectiveness with rigorous methodology, leading to important insights on personalized medicine in real-life.< Réduire

Mots clés en anglais

Asthma

Pharmacoepidemiology

Precision Medicine

Rhinitis

Allergic

Sublingual Immunotherapy

URI

https://oskar-bordeaux.fr/handle/20.500.12278/199772

DOI

http://dx.doi.org/10.1080/1744666x.2023.2294040

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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A successful linkage of a named patient products of sublingual immunotherapy-dispensing registry to French healthcare insurance database (SNDS): methodological constitution of the EfficAPSI cohort

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Résumé en anglais

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