MARTIN-FERNANDEZ, Mario; MENEGOLLA, Ana Paula; LOPEZ-FERNANDEZ, Guillem; WINKE, Nanci; JERCOG, Daniel; KIM, Ha-Rang; GIRARD, Delphine; DEJEAN, Cyril; HERRY, Cyril

doi:10.1038/s41593-023-01472-8

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MARTIN-FERNANDEZ, Mario
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

MENEGOLLA, Ana Paula
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

LOPEZ-FERNANDEZ, Guillem
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Nature Neuroscience. 2023-12, vol. 26, n° 12, p. 2147-2157

Résumé en anglais

Behavioral adaptation to potential threats requires both a global representation of danger to prepare the organism to react in a timely manner but also the identification of specific threatening situations to select the appropriate behavioral responses. The prefrontal cortex is known to control threat-related behaviors, yet it is unknown whether it encodes global defensive states and/or the identity of specific threatening encounters. Using a new behavioral paradigm that exposes mice to different threatening situations, we show that the dorsomedial prefrontal cortex (dmPFC) encodes a general representation of danger while simultaneously encoding a specific neuronal representation of each threat. Importantly, the global representation of danger persisted in error trials that instead lacked specific threat identity representations. Consistently, optogenetic prefrontal inhibition impaired overall behavioral performance and discrimination of different threatening situations without any bias toward active or passive behaviors. Together, these data indicate that the prefrontal cortex encodes both a global representation of danger and specific representations of threat identity to control the selection of defensive behaviors. © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.< Réduire

Mots clés en anglais

Animals

Mice

Neurons* / physiology

Optogenetics

Prefrontal Cortex* / physiology

URI

https://oskar-bordeaux.fr/handle/20.500.12278/199649

DOI

http://dx.doi.org/10.1038/s41593-023-01472-8

Project ANR

Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur - ANR-10-EQPX-0008

Unités de recherche

Neurocentre Magendie - U1215