High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | KOEHLER, Victor | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BRUSCHERA, Gabrielle | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | MERLET, Eric | |
| dc.contributor.author | MANDAL, Pradeep | |
| dc.contributor.author | MORVAN, Estelle | |
| dc.contributor.author | ROSU, Frederic | |
| dc.contributor.author | DOUAT, Celine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | FISCHER, Lucile | |
| dc.contributor.author | HUC, Ivan | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | FERRAND, Yann | |
| dc.date.accessioned | 2024-04-30T09:34:47Z | |
| dc.date.available | 2024-04-30T09:34:47Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 1433-7851 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199529 | |
| dc.description.abstractEn | We prepared a series of water‐soluble aromatic oligoamide sequences all composed of a segment prone to form a single helix and a segment prone to dimerize into a double helix. These sequences exclusively assemble as antiparallel duplexes. The modification of the duplex inner rim by varying the nature of the substituents borne by the aromatic monomers allowed us to identify sequences that can hybridize by combining two chemically different strands, with high affinity and complete selectivity in water. X‐ray crystallography confirmed the expected antiparallel configuration of the duplexes whereas NMR spectroscopy and mass spectrometry allowed us to assess precisely the extent of the hybridization. The hybridization kinetics of the aromatic strands was shown to depend on both the nature of the substituents responsible for strand complementarity and the length of the aromatic strand. These results highlight the great potential of aromatic hetero‐duplexes as a tool to construct non‐symmetrical dynamic supramolecular assemblies. | |
| dc.description.sponsorship | Assemblage dynamique de foldamères oligoamides aromatiques pour la stabilisation d'interactions protéine-protéine - ANR-19-CE07-0034 | en_US |
| dc.language.iso | EN | en_US |
| dc.title.en | High‐Affinity Hybridization of Complementary Aromatic Oligoamide Strands in Water | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/anie.202311639 | en_US |
| dc.subject.hal | Chimie | en_US |
| bordeaux.journal | Angewandte Chemie International Edition | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04234549 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.date=2023&rft.eissn=1433-7851&rft.issn=1433-7851&rft.au=KOEHLER,%20Victor&BRUSCHERA,%20Gabrielle&MERLET,%20Eric&MANDAL,%20Pradeep&MORVAN,%20Estelle&rft.genre=article |
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