Solution behavior and encapsulation properties of fatty acid-elastin-like polypeptide conjugates
| dc.rights.license | open | en_US |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | ZHANG, Tingting | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | PERUCH, Frederic | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | WEBER, Amelie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BATHANY, Katell | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Centre de Recherche Paul Pascal [CRPP] | |
| dc.contributor.author | FAUQUIGNON, Martin | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | MUTSCHLER, Angela
IDREF: 224745379 | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | SCHATZ, Christophe | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Institut Polytechnique de Bordeaux [Bordeaux INP] | |
| dc.contributor.author | GARBAY, Bertrand
ORCID: 0000-0001-5756-2627 IDREF: 033777551 | |
| dc.date.accessioned | 2024-04-29T15:44:02Z | |
| dc.date.available | 2024-04-29T15:44:02Z | |
| dc.date.issued | 2023-01-12 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199513 | |
| dc.description.abstractEn | Developing new biomaterials is an active research area owing to their applications in regenerative medicine, tissue engineering and drug delivery. Elastin-like polypeptides (ELPs) are good candidates for these applications because they are biosourced, biocompatible and biodegradable. With the aim of developing ELP-based micelles for drug delivery applications we have synthesized 15 acyl-ELP compounds by conjugating myristic, palmitic, stearic, oleic or linoleic acid to the N-terminus of three ELPs differing in molar mass. The ELP-fatty acid conjugates have interesting solution behavior. They form micelles at low temperatures and aggregate above the cloud point temperature (Tcp). The critical micelle concentration depends on the fatty acid nature while the micelle size is mainly determined by the ELP block length. We were able to show that ELPs were better hydrated in the micelles than in their individual state in solution. The micelles are stable in phosphate-buffer saline at temperatures below the Tcp, which can vary between 20 °C and 38 °C depending on the length or hydrophilicity of the ELP. Acyl-ELP micelles were loaded with the small hydrophobic molecule Nile red. The encapsulation efficiency and release kinetics showed that the best loading conditions were achieved with the largest ELP conjugated to stearic acid. | |
| dc.language.iso | EN | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/ | |
| dc.subject.en | Elastin-like polypeptides (ELPs) | |
| dc.subject.en | Fatty acids | |
| dc.subject.en | Star-like micelles | |
| dc.subject.en | Self-assembly | |
| dc.subject.en | Nile red encapsulation | |
| dc.title.en | Solution behavior and encapsulation properties of fatty acid-elastin-like polypeptide conjugates | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1039/d2ra06603c | en_US |
| dc.subject.hal | Chimie/Polymères | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | en_US |
| bordeaux.journal | RSC Advances | en_US |
| bordeaux.page | 2190 | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03966126 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=RSC%20Advances&rft.date=2023-01-12&rft.volume=13&rft.issue=3&rft.spage=2190&rft.epage=2190&rft.au=ZHANG,%20Tingting&PERUCH,%20Frederic&WEBER,%20Amelie&BATHANY,%20Katell&FAUQUIGNON,%20Martin&rft.genre=article |
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