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A novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials

dc.rights.licenseopenen_US
dc.contributor.authorSANZ, J.I.R.
dc.contributor.authorCHARID, I.
dc.contributor.authorAMANT, F.
dc.contributor.authorFONAYET, J.V.
dc.contributor.authorSAIDENE, N.
dc.contributor.authorATMANI, D.
dc.contributor.authorRICHARD, T.
dc.contributor.authorMEDJAHED, Zineb
dc.contributor.authorCHAHER-BAZIZI, Nassima
dc.contributor.authorATMANI-KILANI, Dina
dc.contributor.authorAHMANE, Nadjia
dc.contributor.authorRUIZ-LARREA, Marie Begoña
dc.contributor.authorSANZ, José Ignacio Ruiz
dc.contributor.authorCHARID, Imane
dc.contributor.authorAMANT, Frédéric
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorFONAYET, Josep Valls
dc.contributor.authorSAIDENE, Naima
dc.contributor.authorATMANI, Djebbar
hal.structure.identifierUnité de Recherche Œnologie [Villenave d'Ornon] [OENO]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorRICHARD, Tristan
dc.date.accessioned2024-04-16T15:05:46Z
dc.date.available2024-04-16T15:05:46Z
dc.date.issued2023-08
dc.identifier.issn0367-326Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199194
dc.description.abstractEnClematis flammula leaves are traditionally used in Algeria to treat rheumatoid arthritis. Our aim was to identify the main compounds in this plant in order to characterize its antioxidant and anticancer activities. A new flavonol compound, kaempferol 3-O-[(6-O- caffeoyl)- glucosyl(1 → 2)]-(6-Ocaffeoyl) glucoside-7-O-rhamnoside (6) along with six known flavonol molecules were isolated from an ethanolic extract of Clematis flammula leaves. The chemical structures of these flavonols were elucidated using NMR and high resolution-MS spectroscopies. Antioxidant activities of the extract were revealed through its elimination of superoxide radical (O2.-) produced enzymatically (49.7 ± 1.52% at 50 μg/ml) and non-enzymatically (34 ± 1.2% at 100 μg/ml), probably related to its inhibition of the xanthine oxidase form of the xanthine oxidoreductase (XOR) enzyme (25.05 ± 2.33 μg/mL at 100 μg/mL), but mostly to that of the NADH oxidase form of the enzyme (69.16 ± 4.0%). Cytotoxicity tests of the extract on human hepatoma cell line HepG2 and ovarian cancer cell lines A2780 and OVCAR3 were promising especially regarding A2780 cell line (IC50: 77.0 μg/mL), which was comparable to taxol (IC50:76.9 μg/mL). © 2023 Elsevier B.V.
dc.language.isoENen_US
dc.subject.enClematis flammula
dc.subject.enFlavonol glycosides
dc.subject.enXanthine oxydase
dc.subject.enNADH oxydase
dc.subject.enCytotoxicity
dc.title.enA novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.fitote.2023.105642en_US
dc.subject.halSciences du Vivant [q-bio]/Biologie végétaleen_US
bordeaux.journalFitoterapiaen_US
bordeaux.volume170en_US
bordeaux.hal.laboratoriesOenologie - UMR 1366en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04548888
hal.version1
hal.date.transferred2024-04-16T15:05:49Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Fitoterapia&rft.date=2023-08&rft.volume=170&rft.eissn=0367-326X&rft.issn=0367-326X&rft.au=SANZ,%20J.I.R.&CHARID,%20I.&AMANT,%20F.&FONAYET,%20J.V.&SAIDENE,%20N.&rft.genre=article


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