Ultrasound assisted extraction of amino acids and nucleobases from clay minerals and astrobiological samples
hal.structure.identifier | Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]] | |
dc.contributor.author | TIMOUMI, Ramzi | |
hal.structure.identifier | Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]] | |
dc.contributor.author | AMANIAMPONG, Prince Nana | |
hal.structure.identifier | Laboratoire d'Astrophysique de Bordeaux [Pessac] [LAB] | |
dc.contributor.author | LE POSTOLLEC, Aurelie | |
hal.structure.identifier | Laboratoire d'Astrophysique de Bordeaux [Pessac] [LAB] | |
dc.contributor.author | DOBRIJEVIC, Michel | |
hal.structure.identifier | Centre National d'Études Spatiales [Toulouse] [CNES] | |
dc.contributor.author | RIOLAND, Guillaume | |
hal.structure.identifier | Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]] | |
dc.contributor.author | GREGOIRE, Brian | |
hal.structure.identifier | Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]] | |
dc.contributor.author | POINOT, Pauline | |
hal.structure.identifier | Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]] | |
dc.contributor.author | GEFFROY-RODIER, Claude | |
dc.date.issued | 2024-02 | |
dc.identifier.issn | 1350-4177 | |
dc.description.abstractEn | The design of innovative therapeutic strategies enabling the selective destruction of tumor cells while sparing healthy tissues remains highly challenging in cancer therapy. Here, we show that the combination of two targeted therapies, including bevacizumab (Bev), and a beta-glucuronidase-responsive albumin-binding prodrug of monomethyl auristatin E (MMAE), is efficient for the treatment of colorectal cancer implanted in mice. This combined therapy produces a therapeutic activity superior to that of the association of FOLFOX and Bev currently used to treat patients with this pathology. The increased anticancer efficacy is due to either a synergistic or an additive effect between Bev and MMAE selectively released from the glucuronide prodrug in the tumor microenvironment. Since numerous drug delivery systems such as antibody-drug conjugates employ MMAE as a cytotoxic payload, this finding may be of great interest for improving their therapeutic index by combining them with Bev, particularly for the therapy of colorectal cancer. | |
dc.description.sponsorship | Integrative analytical unit for the study of emergent catalytic systems - ANR-22-EXOR-0014 | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.subject.en | UAE Meteorite | |
dc.subject.en | Amino acids | |
dc.subject.en | Nucleobases | |
dc.subject.en | Peptides | |
dc.subject.en | Ultrasound frequency | |
dc.title.en | Ultrasound assisted extraction of amino acids and nucleobases from clay minerals and astrobiological samples | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.ultsonch.2024.106775 | |
dc.subject.hal | Chimie/Chimie analytique | |
dc.subject.hal | Planète et Univers [physics] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Réseaux moléculaires [q-bio.MN] | |
dc.subject.hal | Sciences du Vivant [q-bio]/Cancer | |
bordeaux.journal | Ultrasonics Sonochemistry | |
bordeaux.page | 106775 | |
bordeaux.volume | 103 | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-04508237 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-04508237v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ultrasonics%20Sonochemistry&rft.date=2024-02&rft.volume=103&rft.spage=106775&rft.epage=106775&rft.eissn=1350-4177&rft.issn=1350-4177&rft.au=TIMOUMI,%20Ramzi&AMANIAMPONG,%20Prince%20Nana&LE%20POSTOLLEC,%20Aurelie&DOBRIJEVIC,%20Michel&RIOLAND,%20Guillaume&rft.genre=article |
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