GONI-DE-CERIO, Felipe; MARIANI, Valentina; COHEN, Dror; MADI, Lea; THEVENOT, Julie; OLIVEIRA, Hugo; UBOLDI, Chiara; GIUDETTI, Guido; CORADEGHINI, Rosella; GARANGER, Elisabeth; ROSSI, François; PORTUGAL-COHEN, Meital; ORON, Miriam; KORENSTEIN, Rafi; LECOMMANDOUX, Sebastien; PONTI, Jessica; SUAREZ-MERINO, Blanca; HEREDIA, Pedro

doi:10.1007/s11051-013-2036-0

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

GONI-DE-CERIO, Felipe
GAIKER Technological Centre

MARIANI, Valentina

COHEN, Dror
Ahava Dead Sea Laboratories

Idioma

Article de revue

Este ítem está publicado en

Journal of Nanoparticle Research. 2013, vol. 15

Springer Verlag

Resumen en inglés

Drugs used for chemotherapy normally carry out adverse, undesired effects. Nanotechnology brings about new horizons to tackle cancer disease with a different strategy. One of the most promising approaches is the use of nanocarriers to transport active drugs. These nanocarriers need to have special properties to avoid immune responses and toxicity, and it is critical to study these effects. Nanocarriers may have different nature, but polypeptide-based copolymers have attracted considerable attention for their biocompatibility, controlled and slow biodegrad-ability as well as low toxicity. Little has been done regarding specific nanocarriers toxicity. In this study, we performed a thorough toxicological study of two different block copolymer nanoparticles (NPs); poly(trimethylene carbonate)-block-poly(L-glutamic acid) (PTMC-b-PGA) and poly(ethylene glycol)-block-poly(c-benzyl-L-glutamate) (PEG-b-PBLG) with sizes between 113 and 131 nm. Low blood-serum-protein interaction was observed. Moreover, general toxicity assays and other endpoints (apoptosis or necrosis) showed good biocompatibility for both NPs.< Leer menos

Metadatos

Compartir este ítem

Licencia de uso del documento

Biocompatibility study of two diblock copolymeric nanoparticles for biomedical applications by in vitro toxicity testing.

Idioma

Este ítem está publicado en

Resumen en inglés

URI

DOI

Orígen

Centros de investigación