HÉMERY, Gauvin; KEYES JR, Anthony C.; GARAIO, Eneko; RODRIGO, Irati; GARCIA, Jose Angel; PLAZAOLA, Fernando; GARANGER, Elisabeth; SANDRE, Olivier

doi:10.1021/acs.inorgchem.7b00956

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HÉMERY, Gauvin
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

KEYES JR, Anthony C.
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

GARAIO, Eneko
Elektrizitatea eta Elektronika Saila

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Article de revue

Ce document a été publié dans

Inorganic Chemistry. 2017, vol. 56, n° 14, p. 8232-8243

American Chemical Society

Résumé en anglais

The polyol route is a versatile and up-scalable method to produce large batches of iron oxide nanoparticles with well-defined structures and magnetic properties. Importance of parameters such as temperature and reaction time, heating profile, nature of polyol solvent or of organometallic precursors on nanostructure and properties has already been described in the literature. Yet, the crucial role of water in the forced hydrolysis pathway has never been reported despite its mandatory presence for nanoparticle production. This communication investigates the influence of the water amount and temperature at which it is injected in the reflux system for either a pure polyol solvent system or a mixture with poly(hydroxy)amine. Distinct morphologies of nanoparticles were thereby obtained, from ultra-ultra-small smooth spheres down to 4 nm in diameter to larger ones up to 37 nm. Well-defined multi-core assemblies with narrow grain size dispersity termed nanoflowers were also synthesized. A diverse and large library of samples was obtained by playing with the nature of solvents and amount of added water while keeping all other parameters constant. The different morphologies lead to magnetic nanoparticles suitable for important biomedical applications such as magnetic hyperthermia, MRI contrast agent, or both.< Réduire

Mots clés en anglais

multi-core

nanoflowers

iron oxide

nanoparticles

mono-core

monocore iron oxide nanoparticles

MRI contrast agent

Polyol synthesis

magnetic hyperthermia

multicore iron oxide nanoparticles

iron oxide nanoparticles

magnetic nanoflowers

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19792

DOI

http://dx.doi.org/10.1021/acs.inorgchem.7b00956

Project ANR

Magnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629