Development of a multi-residue method for scrutinizing psychotropic compounds in natural waters
LARDY-FONTAN, S.
Laboratoire National de métrologie et d’Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
Laboratoire National de métrologie et d’Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
VASLIN-REIMANN, S.
Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
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Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
LARDY-FONTAN, S.
Laboratoire National de métrologie et d’Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
Laboratoire National de métrologie et d’Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
VASLIN-REIMANN, S.
Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
BUDZINSKI, Hélène![](/themes/Mirage2//images/PERSO.svg)
Laboratoire de Physico et Toxico-Chimie des systèmes naturels [LPTC]
Environnements et Paléoenvironnements OCéaniques [EPOC]
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Laboratoire de Physico et Toxico-Chimie des systèmes naturels [LPTC]
Environnements et Paléoenvironnements OCéaniques [EPOC]
LALERE, B.
Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
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Laboratoire National de Métrologie et d'Essais (LNE), 1 rue Gaston Boissier, 75724 Paris, France
Langue
EN
Article de revue
Ce document a été publié dans
Journal of Chromatography B Biomedical Sciences and Applications. 2017-03, vol. 1047, p. 160-172
Résumé en anglais
The present work describes a multi-residue SPE-UPLC–MS/MS method aiming at the characterization of 68 compounds in natural waters, including parent compounds as well as their major metabolites and glucuronide conjugates. ...Lire la suite >
The present work describes a multi-residue SPE-UPLC–MS/MS method aiming at the characterization of 68 compounds in natural waters, including parent compounds as well as their major metabolites and glucuronide conjugates. Development was conducted toward the quantitative determination of a broad range of analytes belonging to different class of psychotropic drugs such as benzodiazepines, antidepressants, stimulants, opiates and opioids, anticonvulsants, anti-dementia drugs, analgesic and anti-inflammatory drugs (as anthropic indicators) in the low ng L−1 range of concentration. Satisfactory extraction recoveries >70% were obtained for the majority of analytes (49 out of 68) allowing low limits of quantification. LOQ ranged between 0.1 and 17.8 ng L−1 and were lower than 5 ng L−1 for 94% of investigated analytes. Furthermore, addition of 25 isotopic labeled standards allowed to ensure reliability of the optimized method. Quantification errors were typically below 15% with relative standard variations <10% in intermediate precision conditions. Finally, the developed method was implemented in natural waters; sampling campaigns were conducted in the Seine River as a demonstration of the applicability and adequation of the method for its purpose. As a result, 48 out of 68 analytes were identified or quantified; some of them like memantine, rivastigmine, zolpidem 4-phenyl-carboxylic acid, zolpidem 6-carboxylic acid for one of the first time in surface waters. Among investigated psychotropic compounds and metabolites, tramadol, codeine, oxazepam, venlafaxine, O-desmethylvenlafaxine, gabapentin, carbamazepine and 10,11-dihydro-10,11-dihydroxycarbamazepine were found to be the most abundant.< Réduire
Mots clés en anglais
Pharmaceuticals
Illicit drugs
Metabolites
Multi-residue
Method development
Isotope dilution
SPE
UPLC–MS/MS
Surface water
GEOF