Monitoring live fuel moisture content (LFMC) in Mediterranean area is of great importance for fire risk assessment. LFMC has extensively been estimated based on optical remote sensing data. But the latter can be affected by atmospheric effects. As a complementary data source, microwave data can be used as they are relatively insensitive to atmospheric effects. Yet further evaluations are needed to investigate the potential of microwave observations to monitor LFMC. In this study, we assess the capability of long-term microwave vegetation optical depth (VOD) to capture the temporal variability of in situ measured LFMC in 14 Mediterranean shrub species in southern France during 1996-2014. Microwave-derived VOD at X band (VODX-15) displayed a high sensitivity to LFMC with correlation coefficients of 0.56. Similar evaluations were made using four optical indices computed from the Moderate Resolution Imaging Spectrometer (MODIS) data including normalized difference vegetation index (NDVI), soil adjusted vegetation index (SAVI), visible atmospheric resistant index (VARI), normalized difference water index (NDWI). The comparisons showed that VARI performs better than VODX-15 and other optical indices with highest median of correlation coefficients of 0.65. Overall, this study shows that passive microwave-derived VOD, are efficient proxies for LFMC of Mediterranean shrub species and could be used along with optical indices to evaluate fire risks in the Mediterranean region.< Réduire