Synthetic Polypeptide Polymers as Simplified Analogues of Antimicrobial Peptides
SALAS-AMBROSIO, Pedro
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
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Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
SALAS-AMBROSIO, Pedro
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
BONDUELLE, Colin
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Biomacromolecules. 2020, vol. 21, n° 9, p. 10.1021/acs.biomac.0c00797
American Chemical Society
Résumé en anglais
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This review aims to summarize the fundamental ...Lire la suite >
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This review aims to summarize the fundamental principles concerning the structure and mechanism of action of these AMPs, in order to guide the design of polymeric analogues that organic chemistry can generate. Among those simplified analogues, this review particularly focuses on those made of amino acids called polypeptide polymers: they are showing great potential by providing one of the best biomimetic and bioactive structures for further biomaterials science applications.< Réduire
Mots clés en anglais
anti-infective activity
synthetic polymers
polypeptides
N-carboxyanhydride
anti-infective agents
amphiphilicity
ring-opening polymerization
amino-acid copolymers
Antimicrobial peptides
Project ANR
Analogues Polymériques de Peptides Antimicrobiens à Potentiel Thérapeutique anti-Clostridium difficile - ANR-17-CE07-0039
Origine
Importé de halUnités de recherche