BABILOTTE, Joanna; MARTIN, Benoit; GUDURIC, Vera; BAREILLE, Reine; AGNIEL, Rémy; ROQUES, Samantha; HÉROGUEZ, Valérie; DUSSAUZE, Marc; GAUDON, Manuel; LE NIHOUANNEN, Damien; CATROS, Sylvain

doi:10.1016/j.msec.2020.111334

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BABILOTTE, Joanna
Bioingénierie tissulaire [BIOTIS]

MARTIN, Benoit
Bioingénierie tissulaire [BIOTIS]

GUDURIC, Vera
Bioingénierie tissulaire [BIOTIS]

Langue

Article de revue

Ce document a été publié dans

Materials Science and Engineering: C. 2021, vol. 118, p. 111334 (13 p.)

Elsevier

Résumé en anglais

Additive manufacturing is a rising field in bone tissue engineering. Additive fabrication offers reproducibility, high precision and rapid manufacture of custom patient-specific scaffolds. The development of appropriate composite materials for biomedical applications is critical to reach clinical application of these novel biomaterials. In this work, medical grade poly(lactic-co-glycolic) acid (PLGA) was mixed with hydroxyapatite nanoparticles (nHA) to fabricate 3D porous scaffolds by Fused Deposition Modeling. We have first confirmed that the composite material could be printed in a reproductive manner. Physical characterization demonstrated a low degradation of the material during manufacturing steps and an expected loading and homogeneous distribution of nHA. In vitro biodegradation of the scaffolds showed modifications of morphological and physicochemical properties over time. The composite scaffolds were biocompatible and high cell viability was observed in vitro, as well as a maintain of cell proliferation. As expected, the addition of nHA displayed a positive impact on osteodifferentiation in vitro. Furthermore, a limited inflammatory reaction was observed after subcutaneous implantation of the materials in the rat. Overall, this study suggests that this composite material is suitable for bone tissue engineering applications.< Réduire

Mots clés en anglais

Hydroxyapatite

Polymer

Composite

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19577

DOI

http://dx.doi.org/10.1016/j.msec.2020.111334

Project ANR

Fabrication d'un substitut osseux pour la chirurgie orale par assemblage multi-couches de membranes cellularisées

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629