WANG, Zhiwei; LIN, Min; BONDUELLE, Colin; LI, Rongye; SHI, Zhekun; ZHU, Chenhui; LECOMMANDOUX, Sebastien; LI, Zhibo; SUN, Jing

doi:10.1021/acs.biomac.0c00844

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WANG, Zhiwei
Qingdao University of Science and Technology

LIN, Min
Qingdao University of Science and Technology

BONDUELLE, Colin

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Biomacromolecules. 2020, vol. 21, n° 8, p. 3411-3419

American Chemical Society

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Delicate control over architectures via crystallization-driven self-assembly (CDSA) in aqueous solution, particularly combined with external stimuli, is rare and challenging. Here, we report a stepwise CDSA process thermally initiated from amphiphilic poly(N-allylglycine)-b-poly(N-octylglycine) (PNAG-b-PNOG) conjugated with thiol-terminated triethylene glycol monomethyl ethers ((PNAG-g-EG3)-b-PNOG) in aqueous solution. The diblock copolymers show a reversible thermoresponsive behavior with nearly identical cloud points in both heating and cooling runs. In contrast, the morphology transition of the assemblies is irreversible upon a heating–cooling cycle because of the presence of a confined domain arising from crystalline PNOG, which allows for the achievement of different nanostructured assemblies by the same polymer. We demonstrated that the thermoresponsive property of PNAG-g-EG3 initiates assembly kinetically that is subsequently promoted by crystallization of PNOG thermodynamically. The irreversible morphology transition behavior provides a convenient platform for comparing the cellular uptake efficiency of nanostructured assemblies with various morphologies that are otherwise similar.< Réduire

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Morphology

Crystallization

Solution chemistry

Copolymers

Transmission electron microscopy

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Thermoinduced Crystallization-Driven Self-Assembly of Bioinspired Block Copolymers in Aqueous Solution

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