BRESSELEERS, Jaleesa; BAGHERI, Mahsa; LEBLEU, Coralie; LECOMMANDOUX, Sebastien; SANDRE, Olivier; PIJPERS, Imke A. B.; MASON, Alexander F.; MEEUWISSEN, Silvie; NOSTRUM, Cornelus F. Van; HENNINK, Wim E.; HEST, Jan C. M. Van

doi:10.3390/polym12112572

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BRESSELEERS, Jaleesa
Eindhoven University of Technology [Eindhoven] [TU/e]
Ardena

BAGHERI, Mahsa
Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences [UIPS]
Universiteit Utrecht / Utrecht University [Utrecht]

LEBLEU, Coralie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Article de revue

Ce document a été publié dans

Polymers. 2020, vol. 12, n° 11, p. 2572

MDPI

Résumé en anglais

The careful design of nanoparticles, in terms of size and morphology, is of great importance to developing effective drug delivery systems. The ability to precisely tailor nanoparticles in size and morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic block of mPEG 5 kDa and a varying molecular weight of the hydrophobic p(HPMA-Bz) block (A: 17.1, B: 10.0, C: 5.2 and D: 2.7 kDa) were self-assembled into nanoparticles by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. The nanoparticles from polymer A, increased in size from 55 to 90 nm using lower polymer concentrations and slower flow rates and even polymer vesicles were formed along with micelles. Similarly, nanoparticles from polymer D increased in size from 35 to 70 nm at slower flow rates and also formed vesicles along with micelles, regardless of the used concentration. Differently, polymers B and C mainly self-assembled into micelles at the different applied flow rates with negligible size difference. In conclusion, this study demonstrates that the self-assembly of mPEG-b-p(HPMA-Bz) block copolymers can be easily tailored in size and morphology using microfluidics and is therefore an attractive option for further scaled-up production activities.< Réduire

Mots clés en anglais

size control

nanoprecipitation

nanoparticles

microfluidics

block copolymers

micelles

polymersomes

HPMA

micromixer

URI

https://oskar-bordeaux.fr/handle/20.500.12278/19550

DOI

http://dx.doi.org/10.3390/polym12112572

Projet Européen

Nanomedicine: an integrative approach

Origine

Importé de hal

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629