Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model
| hal.structure.identifier | Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA] | |
| dc.contributor.author | PASQUIER, Jennifer | |
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| dc.contributor.author | MAGAL, Pierre | |
| hal.structure.identifier | Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA] | |
| dc.contributor.author | BOULANGE-LECOMTE, Céline | |
| hal.structure.identifier | Vanderbilt University [Nashville] | |
| dc.contributor.author | WEBB, Glenn | |
| hal.structure.identifier | Sciences Appliquées à L'Environnement [SCALE] | |
| hal.structure.identifier | Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA] | |
| dc.contributor.author | LE FOLL, Frank | |
| dc.date.accessioned | 2024-04-04T03:06:35Z | |
| dc.date.available | 2024-04-04T03:06:35Z | |
| dc.date.issued | 2011 | |
| dc.identifier.issn | 1745-6150 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/193347 | |
| dc.description.abstractEn | Background: Cancer is a proliferation disease affecting a genetically unstable cell population, in which molecular alterations can be somatically inherited by genetic, epigenetic or extragenetic transmission processes, leading to a cooperation of neoplastic cells within tumoural tissue. The efflux protein P-glycoprotein (P-gp) is overexpressed in many cancer cells and has known capacity to confer multidrug resistance to cytotoxic therapies. Recently, cell-to-cell P-gp transfers have been shown. Herein, we combine experimental evidence and a mathematical model to examine the consequences of an intercellular P-gp trafficking in the extragenetic transfer of multidrug resistance from resistant to sensitive cell subpopulations. | |
| dc.language.iso | en | |
| dc.publisher | BioMed Central | |
| dc.subject.en | Doxorubicin | |
| dc.subject.en | Multidrug Resistance | |
| dc.subject.en | Resistant Cell | |
| dc.subject.en | Sensitive Cell | |
| dc.subject.en | Activity Transfer | |
| dc.title.en | Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1186/1745-6150-6-5 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie cellulaire/Interactions cellulaires [q-bio.CB] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Cancer | |
| dc.subject.hal | Mathématiques [math]/Systèmes dynamiques [math.DS] | |
| bordeaux.journal | Biology Direct | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01738512 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01738512v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biology%20Direct&rft.date=2011&rft.eissn=1745-6150&rft.issn=1745-6150&rft.au=PASQUIER,%20Jennifer&MAGAL,%20Pierre&BOULANGE-LECOMTE,%20C%C3%A9line&WEBB,%20Glenn&LE%20FOLL,%20Frank&rft.genre=article |
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