PASQUIER, Jennifer; MAGAL, Pierre; BOULANGE-LECOMTE, Céline; WEBB, Glenn; LE FOLL, Frank

doi:10.1186/1745-6150-6-5

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PASQUIER, Jennifer
Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]

MAGAL, Pierre
Institut de Mathématiques de Bordeaux [IMB]

BOULANGE-LECOMTE, Céline
Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]

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Biology Direct. 2011

BioMed Central

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Background: Cancer is a proliferation disease affecting a genetically unstable cell population, in which molecular alterations can be somatically inherited by genetic, epigenetic or extragenetic transmission processes, leading to a cooperation of neoplastic cells within tumoural tissue. The efflux protein P-glycoprotein (P-gp) is overexpressed in many cancer cells and has known capacity to confer multidrug resistance to cytotoxic therapies. Recently, cell-to-cell P-gp transfers have been shown. Herein, we combine experimental evidence and a mathematical model to examine the consequences of an intercellular P-gp trafficking in the extragenetic transfer of multidrug resistance from resistant to sensitive cell subpopulations.< Leer menos

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Doxorubicin

Multidrug Resistance

Resistant Cell

Sensitive Cell

Activity Transfer

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Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model

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