Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model
LE FOLL, Frank
Sciences Appliquées à L'Environnement [SCALE]
Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]
< Reduce
Sciences Appliquées à L'Environnement [SCALE]
Laboratoire d'Ecotoxicologie - Milieux Aquatiques [LEMA]
Language
en
Article de revue
This item was published in
Biology Direct. 2011
BioMed Central
English Abstract
Background: Cancer is a proliferation disease affecting a genetically unstable cell population, in which molecular alterations can be somatically inherited by genetic, epigenetic or extragenetic transmission processes, ...Read more >
Background: Cancer is a proliferation disease affecting a genetically unstable cell population, in which molecular alterations can be somatically inherited by genetic, epigenetic or extragenetic transmission processes, leading to a cooperation of neoplastic cells within tumoural tissue. The efflux protein P-glycoprotein (P-gp) is overexpressed in many cancer cells and has known capacity to confer multidrug resistance to cytotoxic therapies. Recently, cell-to-cell P-gp transfers have been shown. Herein, we combine experimental evidence and a mathematical model to examine the consequences of an intercellular P-gp trafficking in the extragenetic transfer of multidrug resistance from resistant to sensitive cell subpopulations.Read less <
English Keywords
Doxorubicin
Multidrug Resistance
Resistant Cell
Sensitive Cell
Activity Transfer
Origin
Hal imported