A Parallel Voronoi-Based Approach for Mesoscale Simulations of Cell Aggregate Electropermeabilization
Idioma
en
Article de revue
Este ítem está publicado en
Journal of Computational Physics. 2019-01
Elsevier
Resumen en inglés
We introduce a numerical framework that enables unprecedented direct numerical studies of the electropermeabilization effects of a cell aggregate at the meso-scale. Our simulations qualitatively replicate the shadowing ...Leer más >
We introduce a numerical framework that enables unprecedented direct numerical studies of the electropermeabilization effects of a cell aggregate at the meso-scale. Our simulations qualitatively replicate the shadowing effect observed in experiments and reproduce the time evolution of the impedance of the cell sample in agreement with the trends observed in experiments. This approach sets the scene for performing homogenization studies for understanding the effect of tissue environment on the efficiency of electropermeabilization. We employ a forest of Octree grids along with a Voronoi mesh in a parallel environment that exhibits excellent scalability. We exploit the electric interactions between the cells through a nonlinear phenomenological model that is generalized to account for the permeability of the cell membranes. We use the Voronoi Interface Method (VIM) to accurately capture the sharp jump in the electric potential on the cell boundaries. The case study simulation covers a volume of 1cube millimeter with more than 27000 well-resolved cells with a heterogeneous mix of morphologies that are randomly distributed throughout a spheroid region.< Leer menos
Palabras clave en inglés
Mathematical Biology
Electropermeabilization
Finite Volume Method
Voronoi Mesh
Level-Set Method
Quad/Oc-tree Grids
Orígen
Importado de HalCentros de investigación