GINIP, a Gαi-Interacting Protein, Functions as a Key Modulator of Peripheral GABAB Receptor-Mediated Analgesia
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Institut de Biologie du Développement de Marseille [IBDM] | |
dc.contributor.author | GAILLARD, Stéphane | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Institut de Biologie du Développement de Marseille [IBDM] | |
dc.contributor.author | LO RE, Laure | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | MANTILLERI, Annabelle | |
hal.structure.identifier | Neurobiologie des processus adaptatifs [NPA] | |
dc.contributor.author | HEPP, Régine | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | URIEN, Louise | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
dc.contributor.author | MALAPERT, Pascale | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Développement et pathologies du système nerveux : croissance, signalisation et innovation moléculaire | |
dc.contributor.author | ALONSO, Serge | |
dc.contributor.author | DEAGE, Michael | |
dc.contributor.author | KAMBRUN, Charline | |
hal.structure.identifier | Physiopathologie des Reseaux Neuronaux Medullaires | |
dc.contributor.author | LANDRY, Marc | |
dc.contributor.author | LOW, Sarah A | |
hal.structure.identifier | Pharmacologie fondamentale et clinique de la douleur | |
dc.contributor.author | ALLOUI, Abdelkrim | |
hal.structure.identifier | Neurobiologie des processus adaptatifs [NPA] | |
dc.contributor.author | LAMBOLEZ, Bertrand | |
hal.structure.identifier | Departments of Anatomy and Physiology and W. M. Keck Center for Integrative Neuroscience | |
dc.contributor.author | SCHERRER, Grégory | |
dc.contributor.author | LE FEUVRE, Yves | |
hal.structure.identifier | Institut de Génomique Fonctionnelle [IGF] | |
dc.contributor.author | BOURINET, Emmanuel | |
hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
hal.structure.identifier | Institut de Biologie du Développement de Marseille [IBDM] | |
dc.contributor.author | MOQRICH, Aziz | |
dc.date.accessioned | 2024-04-04T03:04:03Z | |
dc.date.available | 2024-04-04T03:04:03Z | |
dc.date.issued | 2014-09-17 | |
dc.identifier.issn | 0896-6273 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/193116 | |
dc.description.abstractEn | One feature of neuropathic pain is a reduced GABAergic inhibitory function. Nociceptors have been suggested to play a key role in this process. However, the mechanisms behind nociceptor-mediated modulation of GABA signaling remain to be elucidated. Here we describe the identification of GINIP, a Gαi-interacting protein expressed in two distinct subsets of nonpeptidergic nociceptors. GINIP null mice develop a selective and prolonged mechanical hypersensitivity in models of inflammation and neuropathy. GINIP null mice show impaired responsiveness to GABAB, but not to delta or mu opioid receptor agonist-mediated analgesia specifically in the spared nerve injury (SNI) model. Consistently, GINIP-deficient dorsal root ganglia neurons had lower baclofen-evoked inhibition of high-voltage-activated calcium channels and a defective presynaptic inhibition of lamina IIi interneurons. These results further support the role of unmyelinated C fibers in injury-induced modulation of spinal GABAergic inhibition and identify GINIP as a key modulator of peripherally evoked GABAB-receptors signaling. | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights.uri | http://creativecommons.org/licenses/by/ | |
dc.subject.en | Nonpeptidergic nociceptors | |
dc.subject.en | GINIP | |
dc.subject.en | Mice | |
dc.subject.en | Injury | |
dc.subject.en | Analgesia | |
dc.title.en | GINIP, a Gαi-Interacting Protein, Functions as a Key Modulator of Peripheral GABAB Receptor-Mediated Analgesia | |
dc.type | Article de revue | |
dc.identifier.doi | 10.1016/j.neuron.2014.08.056 | |
dc.subject.hal | Sciences du Vivant [q-bio]/Biologie cellulaire | |
dc.description.sponsorshipEurope | Functional significance of nociceptive primary sensory neurons diversity | |
bordeaux.journal | Neuron | |
bordeaux.page | 123–136 | |
bordeaux.volume | 84 | |
bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
bordeaux.issue | 1 | |
bordeaux.institution | Université de Bordeaux | |
bordeaux.institution | Bordeaux INP | |
bordeaux.institution | CNRS | |
bordeaux.peerReviewed | oui | |
hal.identifier | hal-01071132 | |
hal.version | 1 | |
hal.popular | non | |
hal.audience | Internationale | |
hal.origin.link | https://hal.archives-ouvertes.fr//hal-01071132v1 | |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2014-09-17&rft.volume=84&rft.issue=1&rft.spage=123%E2%80%93136&rft.epage=123%E2%80%93136&rft.eissn=0896-6273&rft.issn=0896-6273&rft.au=GAILLARD,%20St%C3%A9phane&LO%20RE,%20Laure&MANTILLERI,%20Annabelle&HEPP,%20R%C3%A9gine&URIEN,%20Louise&rft.genre=article |
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