LE FOLL, Frank; HINOW, Peter; FOLL, Frank Le; MAGAL, Pierre; WEBB, Glenn

doi:10.1137/080732420

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LE FOLL, Frank
Sciences Appliquées à L'Environnement [SCALE]
Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO]

HINOW, Peter
Department of Mathematics [Minneapolis]

FOLL, Frank Le
Sciences Appliquées à L'Environnement [SCALE]

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SIAM Journal on Applied Mathematics. 2009-04-15, vol. 70, n° 1, p. 40-62

Society for Industrial and Applied Mathematics

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We study the problem of transfer in a population structured by a continuum variable corresponding to the quantity being transferred. The transfer of the quantity occurs between individuals according to specified rules. The model is of Boltzmann type with kernels corresponding to the transfer process. We prove that the transfer process preserves total mass of the transferred quantity and the solutions of the simple model converge weakly to Radon measures. We generalize the model by introducing proliferation of individuals and production and diffusion of the transferable quantity. It is shown that the generalized model admits a globally asymptotically stable steady state, provided that transfer is sufficiently small. We discuss an application of our model to cancer cell populations, in which individual cells exchange the surface protein P-glycoprotein, an important factor in acquired multidrug resistance against cancer chemotherapy.< Leer menos

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Analysis of a Model for Transfer Phenomena in Biological Populations

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