PERI, Daniele; DEVILLE, Manon; POIGNARD, Clair; SIGNORI, Emanuela; NATALINI, Roberto

doi:10.1016/j.cmpb.2019.105204

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PERI, Daniele
Istituto per le Applicazioni del Calcolo "Mauro Picone" [IAC]

DEVILLE, Manon
Modélisation Mathématique pour l'Oncologie [MONC]

POIGNARD, Clair
Modélisation Mathématique pour l'Oncologie [MONC]

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Computer Methods and Programs in Biomedicine. 2019-11p. 105204

Elsevier

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Background and Objective: The paper focuses on the numerical strategies to optimize a plasmid DNA delivery protocol, which combines hyaluronidase and electroporation. Methods: A well-defined continuum mechanics model of muscle porosity and advanced numerical optimization strategies have been used, to propose a substantial improvement of a pre-existing experimental protocol of DNA transfer in mice. Our work suggests that a computational model might help in the definition of innovative therapeutic procedures, thanks to the fine tuning of all the involved experimental steps. This approach is particularly interesting in optimizing complex and costly protocols, to make in vivo DNA therapeutic protocols more effective. Results: Our preliminary work suggests that computational model might help in the definition of innovative therapeutic protocol, thanks to the fine tuning of all the involved operations. Conclusions: This approach is particularly interesting in optimizing complex and costly protocols for which the number of degrees of freedom prevents a experimental test of the possible configuration.< Réduire

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Numerical Optimization of Plasmid DNA Delivery Combined with Hyaluronidase Injection for Electroporation Protocol

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