DAVIDOVIĆ, Anđela; COUDIÈRE, Yves; BOURGAULT, Yves

doi:10.1002/cnm.3322

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DAVIDOVIĆ, Anđela
Institut de Mathématiques de Bordeaux [IMB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
Institut Pasteur [Paris] [IP]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]

COUDIÈRE, Yves
Institut de Mathématiques de Bordeaux [IMB]
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]

BOURGAULT, Yves
University of Ottawa [Ottawa]

Langue

Article de revue

Ce document a été publié dans

International Journal for Numerical Methods in Biomedical Engineering. 2020-02-12p. e3322

John Wiley and Sons

Résumé en anglais

Mathematical modelling and numerical simulation in cardiac electrophysiology have already been studied extensively. However, there is a clear lack of techniques and methodologies for studying the propagation of action potential in a heart with structural defects. In this article, we present a modified version of the bidomain model, derived using homogenisation techniques with the assumption of existence of diffusive inclusions in the cardiac tissue. The diffusive inclusions represent regions without electrically active myocytes, for example, fat, fibrosis, and so forth. We present an application of this model to a rat heart. Starting from high-resolution MRI, the geometry of the heart is built and meshed using image processing techniques. We perform a study of the effects of tissue heterogeneities induced by diffusive inclusions on the velocity and shape of the depolarisation wavefront. We present several test cases with different geometries of diffusive inclusions. We reach the conclusion that the conduction velocity is not affected in the best cases, while it is affected by up to 76% in the worst case scenario. Additionally, the shape of the wavefront was affected in some cases.< Réduire

Mots clés en anglais

Bidomain model

Fibrosis

Heterogeneous conductivities

Image-based modelling

Multiscale modelling

URI

https://oskar-bordeaux.fr/handle/20.500.12278/191415

DOI

http://dx.doi.org/10.1002/cnm.3322

Project ANR

Modèles numériques haute résolution de l'électrophysiologie cardiaque - ANR-13-MONU-0004
L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004

Origine

Importé de hal

Unités de recherche

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251