DUFRESNE, Suzanne; RICHARD, Cindy; DIEUMEGARD, Arthur; ORFILA, Luz; DELPON, Gregory; CHIAVASSA, Sophie; MARTIN, Brice; ROUVIÈRE, Laurent; ESCOFFRE, Jean-Michel; OUJAGIR, Edward; DENIS DE SENNEVILLE, Baudouin; BOUAKAZ, Ayache; RIOUX-LECLERCQ, Nathalie; POTIRON, Vincent; RÉBILLARD, Amélie

doi:10.3390/cancers13215402

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DUFRESNE, Suzanne
Laboratoire Mouvement Sport Santé [M2S]

RICHARD, Cindy
Laboratoire Mouvement Sport Santé [M2S]

DIEUMEGARD, Arthur
Laboratoire Mouvement Sport Santé [M2S]

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Ce document a été publié dans

Cancers. 2021-10-28, vol. 13, n° 21, p. 5402

MDPI

Résumé en anglais

Physical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) could improve tumor perfusion and enhance radiotherapy (RT) efficiency. Nude athymic mice were injected with PC-3 cancer cells and either remained inactive or were housed with running wheels. Apparent microbubble transport was enhanced with VWR, which we hypothesized could improve the RT response. When repeating the experiments and adding RT, however, we observed that VWR did not influence RT efficiency. These findings contrasted with previous results and prompted us to evaluate if the lack of effects observed on tumor growth could be attributable to the physical activity modality used. Using PC-3 and PPC-1 xenografts, we randomized mice to either inactive controls, VWR, or treadmill running (TR). In both models, TR (but not VWR) slowed down tumor growth, suggesting that the anti-cancer effects of physical activity are dependent on its modalities. Providing a better understanding of which activity type should be recommended to cancer patients thus appears essential to improve treatment outcomes.< Réduire

Mots clés en anglais

radiotherapy

prostate cancer

exercise

physical activity

radiation therapy

vascularization

proliferation

URI

https://oskar-bordeaux.fr/handle/20.500.12278/191406

DOI

http://dx.doi.org/10.3390/cancers13215402

Project ANR

Centre de Mathématiques Henri Lebesgue : fondements, interactions, applications et Formation - ANR-11-LABX-0020

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Importé de hal

Unités de recherche

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251