BOSMA, Lando; ZACHIU, Cornel; RIES, Mario; DENIS DE SENNEVILLE, Baudouin; RAAYMAKERS, Bas

doi:10.1088/1361-6560/abe02a

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Physics in Medicine and Biology. 2021-10, vol. 66, n° 6, p. 065002

IOP Publishing

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Accurate spatial dose delivery in radiotherapy is frequently complicated due to changes in the patient's internal anatomy during and in-between therapy segments. The recent introduction of hybrid MRI radiotherapy systems allows unequaled soft-tissue visualization during radiation delivery and can be used for dose reconstruction to quantify the impact of motion. To this end, knowledge of anatomical deformations obtained from continuous monitoring during treatment has to be combined with information on the spatio-temporal dose delivery to perform motion-compensated dose accumulation (MCDA). Here, the influence of the choice of deformable image registration algorithm, dose warping strategy, and MR image resolution and SNR on the resulting MCDA is investigated. For a quantitative investigation, four 4D MRI-datasets representing typical patient observed motion patterns are generated using finite element modeling and serve as a gold standard. Energy delivery is simulated intra-fractionally in the deformed image space and, subsequently, MCDA-processed. Finally, the results are substantiated by comparing MCDA strategies on clinically acquired patient data. It is shown that MCDA is needed for correct quantitative dose reconstruction. For prostate treatments, using the energy per mass transfer dose warping strategy has the largest influence on decreasing dose estimation errors.< Réduire

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Motion-compensated dose accumulation

intra-fraction plan adaption

MRguided radiotherapy

dose reconstruction

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Quantitative investigation of dose accumulation errors from intra-fraction motion in MRgRT for prostate cancer

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