CALUORI, Guido; COLLIN, Annabelle; POIGNARD, Clair; JAIS, Pierre

doi:10.1007/978-981-19-6649-1_2

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CALUORI, Guido
Institut de rythmologie et modélisation cardiaque [Pessac] [IHU Liryc]

COLLIN, Annabelle
Modélisation Mathématique pour l'Oncologie [MONC]

POIGNARD, Clair
Modélisation Mathématique pour l'Oncologie [MONC]

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Innovative Treatment Strategies for Clinical Electrophysiology, Innovative Treatment Strategies for Clinical Electrophysiology. 2022-12-07p. 29-47

Springer Nature Singapore

Résumé en anglais

Pulsed field ablation is a recent addition to the techniques used to ablate pathological arrhythmic circuits. Despite its recent introduction in the clinical field, pulsed field ablation exploits the well-known phenomenon of irreversible electropo- ration and the less known phenomena of selective cell death.Far from being only used in cardiology, irreversible electroporation is mainly exploited in the treatment of solid tumors. Nevertheless, the tissue specificity of the technique with respect to muscular cells presented such a favourable benefits-to-risk ratio that fundamental questions (e.g., What causes cell death? Can we model it to predict the ablation lesion?) were put on hold in favour of preclinical testing and first clinical applications.In this chapter, we explore the current knowledge of irreversible electroporation mechanisms and their modeling, keeping our focus on the research that put the basis and is setting the roadmap for pulsed field ablation in its promise to revolutionize the interventional treatment of arrhythmia.< Réduire

Mots clés en anglais

cardiac ablation

electroporation

pulse field ablation

electroporation modeling

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Pulsed Field Ablation for the Interventional Treatment of Cardiac Arrhythmias

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