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Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.

hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorNAZARET, Christine
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorHEISKE, Margit
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorTHURLEY, Kevin
hal.structure.identifierPhysiopathologie mitochondriale
dc.contributor.authorMAZAT, Jean-Pierre
dc.date.accessioned2024-04-04T02:29:19Z
dc.date.available2024-04-04T02:29:19Z
dc.date.issued2009-06-07
dc.identifier.issn0022-5193
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/190164
dc.description.abstractEnMitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.
dc.language.isoen
dc.publisherElsevier
dc.subject.meshAdenosine Triphosphate
dc.subject.meshAnimals
dc.subject.meshCitric Acid Cycle
dc.subject.meshComputer Simulation
dc.subject.meshEnergy Metabolism
dc.subject.meshHumans
dc.subject.meshMitochondria
dc.subject.meshModels, Biological
dc.subject.meshOxygen Consumption
dc.title.enMitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.
dc.typeArticle de revue
dc.identifier.doi10.1016/j.jtbi.2008.09.037
dc.subject.halMathématiques [math]/Systèmes dynamiques [math.DS]
dc.subject.halSciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
dc.subject.halInformatique [cs]/Bio-informatique [q-bio.QM]
bordeaux.journalJournal of Theoretical Biology
bordeaux.page455-64
bordeaux.volume258
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.issue3
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-00462362
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00462362v1
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