ZEMZEMI, Nejib; SAIZ RODRIGUEZ, Javier; BLANCA, Rodriguez

Métadonnées

Licence d’utilisation du document

ZEMZEMI, Nejib
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]

SAIZ RODRIGUEZ, Javier
Universitat Politècnica de València = Universitad Politecnica de Valencia = Polytechnic University of Valencia [UPV]

BLANCA, Rodriguez
Computing Science Laboratory - Oxford University

Langue

Communication dans un congrès

Ce document a été publié dans

Computing in Cardiology (CinC), 2012, Computing in Cardiology (CinC), 2012, CinC 2012 - Computing in Cardiology, 2012-09-09, Krakow. 2012-10-17p. 861-864

IEEE

Résumé en anglais

Dofetilide is a class III drug whose use needs to be monitored due to the possible occurrence of Torsades de Pointes (TdP). The mechanisms are unclear but research suggests that both early-afterdepolarizations (EAD) and increased dispersion of action potential duration (APD) might be involved. Importantly, drug-induced TdP is more common in women, possibly due to higher L-type calcium current (ICaL) levels. Our goal is to use numerical simula- tion in order to investigate pro-arrhythmic mechanisms of dofetilide in human by characterizing its effects on APD, APD dispersion and EAD formation for varying doses and ICaL levels.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/189753

Projet Européen

Computational Prediction of Drug Cardiac Toxicity

Origine

Importé de hal

Unités de recherche

Institut de Mathématiques de Bordeaux (IMB) - UMR 5251