NICOLAS, Celine; JU, Anes; WU, Yifan; ELDIRDIRI, Hazim; DELCASSO, Sebastien; COUDERC, Yoni; FORNARI, Claudia; MITRA, Arojit; SUPIOT, Laura; VÉRITÉ, Adrien; MASSON, Maxime; RODRIGUEZ-ROZADA, S.; JACKY, Debora; WIEGERT, J.S.; BEYELER, Anna

doi:10.1038/s41467-023-40517-1

NICOLAS, Celine
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

JU, Anes

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

WU, Yifan

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

Langue

Article de revue

Ce document a été publié dans

Nature Communications. 2023-08-21, vol. 14, n° 1, p. 5073

Résumé en anglais

Responses of the insular cortex (IC) and amygdala to stimuli of positive and negative valence are altered in patients with anxiety disorders. However, neural coding of both anxiety and valence by IC neurons remains unknown. Using fiber photometry recordings in mice, we uncover a selective increase of activity in IC projection neurons of the anterior (aIC), but not posterior (pIC) section, when animals are exploring anxiogenic spaces, and this activity is proportional to the level of anxiety of mice. Neurons in aIC also respond to stimuli of positive and negative valence, and the strength of response to strong negative stimuli is proportional to mice levels of anxiety. Using ex vivo electrophysiology, we characterized the IC connection to the basolateral amygdala (BLA), and employed projection-specific optogenetics to reveal anxiogenic properties of aIC-BLA neurons. Finally, we identified that aIC-BLA neurons are activated in anxiogenic spaces, as well as in response to aversive stimuli, and that both activities are positively correlated. Altogether, we identified a common neurobiological substrate linking negative valence with anxiety-related information and behaviors, which provides a starting point to understand how alterations of these neural populations contribute to psychiatric disorders. © 2023, Springer Nature Limited.< Réduire

Mots clés en anglais

Amygdala

Animals

Anxiety

Anxiety Disorders

Emotions

Insular Cortex

Mice

URI

https://oskar-bordeaux.fr/handle/20.500.12278/189092

DOI

http://dx.doi.org/10.1038/s41467-023-40517-1

Unités de recherche

Neurocentre Magendie - U1215

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Linking emotional valence and anxiety in a mouse insula-amygdala circuit

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche