MANANGAMA, Guyguy; GALERA, Cedric; AUDIGNON, Sabyne; GRAMOND, Celine; TARTAGLIA, Marie; ZAROS, Cecile; TEYSSEIRE, Raphaelle; BROCHARD, Patrick; SENTILHES, Loic; DELVA, Fleur

doi:10.1016/j.envres.2024.118364

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MANANGAMA, Guyguy
Bordeaux population health [BPH]

GALERA, Cedric

Bordeaux population health [BPH]

AUDIGNON, Sabyne
Bordeaux population health [BPH]

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Environmental Research. 2024-02-02, vol. 248, p. 118364

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OBJECTIVE: To investigate the association between occupational exposures to carbonaceous unintentionally emitted nanoscale particles (UNPs) during pregnancy and the child's language development and behaviour at two years old. METHODS: Using data from the French Longitudinal Study of Childhood - ELFE, we selected mothers who worked during pregnancy and their children. Exposure to carbonaceous UNPs was assessed by the MatPUF (job-exposure matrix for ultrafine particles). Children's lexical development was analysed using 'the Mac Arthur - Bates communicative development inventories-words and sentences-short form' (MB-CDI) in a multivariate binary logistic regression. Their risk for autism spectrum disorders was studied using 'the Modified-CHecklist for Autism in Toddler' (M-CHAT) according to the recommended thresholds (low risk = 0-2; intermediate risk = 3-6 and high risk = 7-23) in unordered multinomial logistic regression models. RESULTS: Maternal occupational exposure to carbonaceous UNPs was associated with delayed child language development (ORadj: 1.34; 95 % CI: 1.00, 1.80) but not with behavioural disorders (autism spectrum disorders) at two years old. CONCLUSION: This is the first epidemiological study to show a significant association between maternal occupational exposure to carbonaceous nanoscale particles and child language development at 2 years old.< Réduire

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Carbonaceous nanoscale particles

ELFE cohort

Neurodevelopmental disorders

Occupational exposure

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Maternal occupational exposure to carbonaceous nanoscale particles and neurodevelopmental outcomes in early childhood: Analysis of the French Longitudinal Study of Children - Elfe study

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