PIERRON, Fabien; DAFFE, Guillemine; DARAMY, Flore; HEROIN, Debora; BARRÉ, Aurélien; BOUCHEZ, Olivier; CLERENDEAU, Christelle; ROMERO-RAMIREZ, Alicia; NIKOLSKI, Macha

doi:10.1016/j.jhazmat.2023.131579

Environnements et Paléoenvironnements OCéaniques [EPOC]

DAFFE, Guillemine
Pluridisciplinarité au service de l’observation et de la recherche en environnement et astronomie [UMS POREA]

DARAMY, Flore
Environnements et Paléoenvironnements OCéaniques [EPOC]

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Article de revue

Ce document a été publié dans

Journal of Hazardous Materials. 2023, vol. 455, p. 131579

Résumé en anglais

Evidence has emerged that environmentally-induced epigenetic changes can have long-lasting effects on gene transcription across generations. These recent findings highlight the need to investigate the transgenerational impacts of pollutants to assess their long term effects on populations. In this study, we investigated the transgenerational effect of cadmium on zebrafish across 4 generations. A first whole methylome approach carried out on fish of the first two generations led us to focus our investigations on the estradiol receptor alpha gene (esr1). We observed a sex-dependent transgenerational inheritance of Cd-induced DNA methylation changes up to the last generation. These changes were associated with single nucleotide polymorphisms (SNPs) that were themselves at the origin of the creation or deletion of methylation sites. Thus, Cd-induced genetic selection gave rise to DNA methylation changes. We also analyzed the transcription level of various sections of esr1 as well as estrogen responsive genes. While Cd triggered transgenerational disorders, Cd-induced epigenetic changes in esr1 contributed to the rapid transgenerational adaptation of fish to Cd. Our results provide insight into the processes underpinning rapid adaptation and highlight the need to maintain genetic diversity within natural populations to bolster the resilience of species faced with the global environmental changes.< Réduire

Mots clés en anglais

Transgenerational inheritance

DNA methylation

endocrine disruptor

rapid adaptation

genetic selection

URI

https://oskar-bordeaux.fr/handle/20.500.12278/187813

DOI

http://dx.doi.org/10.1016/j.jhazmat.2023.131579

Project ANR

Effets transgénérationnels des polluants chez les poissons: l'épigénétique et son implication en écotoxicologie - ANR-16-CE34-0008

Unités de recherche

EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805

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Transgenerational endocrine disruptor effects of cadmium in zebrafish and contribution of standing epigenetic variation to adaptation