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Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites
dc.rights.license | open | en_US |
hal.structure.identifier | Plasticité du Génome Bactérien - Bacterial Genome Plasticity [PGB] | |
dc.contributor.author | LOOT, Céline | |
hal.structure.identifier | Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB | |
dc.contributor.author | MILLOT, Gael | |
hal.structure.identifier | Plasticité du Génome Bactérien - Bacterial Genome Plasticity [PGB] | |
hal.structure.identifier | Collège Doctoral | |
dc.contributor.author | RICHARD, Egill | |
hal.structure.identifier | Génomique évolutive des Microbes / Microbial Evolutionary Genomics | |
hal.structure.identifier | Collège Doctoral | |
hal.structure.identifier | Centre d'Études du Bouchet [DGA Maitrise NRBC] | |
dc.contributor.author | LITTNER, Eloi | |
hal.structure.identifier | Plasticité du Génome Bactérien - Bacterial Genome Plasticity [PGB] | |
hal.structure.identifier | Collège Doctoral | |
dc.contributor.author | VIT, Claire | |
hal.structure.identifier | Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB | |
dc.contributor.author | LEMOINE, Frédéric | |
hal.structure.identifier | Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB | |
dc.contributor.author | NÉRON, Bertrand | |
hal.structure.identifier | Laboratoire de Recherche en Informatique [LRI] | |
hal.structure.identifier | Inria de Paris | |
dc.contributor.author | CURY, Jean | |
hal.structure.identifier | Plasticité du Génome Bactérien - Bacterial Genome Plasticity [PGB] | |
hal.structure.identifier | Collège Doctoral | |
dc.contributor.author | DARRACQ, Baptiste | |
hal.structure.identifier | Plasticité du Génome Bactérien - Bacterial Genome Plasticity [PGB] | |
hal.structure.identifier | Collège Doctoral | |
dc.contributor.author | NIAULT, Théophile | |
hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
hal.structure.identifier | Viral DNA Integration and Chromatin Dynamics Network [DyNAVir] | |
dc.contributor.author | LAPAILLERIE, Delphine | |
hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
hal.structure.identifier | Viral DNA Integration and Chromatin Dynamics Network [DyNAVir] | |
dc.contributor.author | PARISSI, Vincent | |
hal.structure.identifier | Génomique évolutive des Microbes / Microbial Evolutionary Genomics | |
dc.contributor.author | ROCHA, Eduardo | |
hal.structure.identifier | Plasticité du Génome Bactérien - Bacterial Genome Plasticity [PGB] | |
dc.contributor.author | MAZEL, Didier | |
dc.date.accessioned | 2024-01-15T12:28:14Z | |
dc.date.available | 2024-01-15T12:28:14Z | |
dc.date.issued | 2024-01-03 | |
dc.identifier.issn | 2058-5276 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/187165 | |
dc.description.abstractEn | Integrons are genetic elements involved in bacterial adaptation which capture, shuffle and express genes encoding adaptive functions embedded in cassettes. These events are governed by the integron integrase through site-specific recombination between attC and attI integron sites. Using computational and molecular genetic approaches, here we demonstrate that the integrase also catalyses cassette integration into bacterial genomes outside of its known att sites. Once integrated, these cassettes can be expressed if located near bacterial promoters and can be excised at the integration point or outside, inducing chromosomal modifications in the latter case. Analysis of more than 5 × 10 5 independent integration events revealed a very large genomic integration landscape. We identified consensus recombination sequences, named attG sites, which differ greatly in sequence and structure from classical att sites. These results unveil an alternative route for dissemination of adaptive functions in bacteria and expand the role of integrons in bacterial evolution. | |
dc.description.sponsorship | Organisation et montée en puissance d'une Infrastructure Nationale de Génomique | en_US |
dc.description.sponsorship | Etude de l'impact des intégrons chromosiques sur l'évolution des bactéries - ANR-21-CE12-0002 | en_US |
dc.description.sponsorship | Integrative Biology of Emerging Infectious Diseases - ANR-10-LABX-0062 | en_US |
dc.language.iso | EN | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/ | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Genome | |
dc.subject.mesh | Genomics | |
dc.subject.mesh | Integrases | |
dc.subject.mesh | Integrons | |
dc.title.en | Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1038/s41564-023-01548-y | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie moléculaire | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
bordeaux.journal | Nature Microbiology | en_US |
bordeaux.page | 228-240 | en_US |
bordeaux.volume | 9 | en_US |
bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
bordeaux.issue | 1 | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | hal | |
hal.identifier | pasteur-04384854 | |
hal.version | 1 | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
workflow.import.source | hal | |
dc.rights.cc | Pas de Licence CC | en_US |
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