AKCHA, F.; CAHUC, C.; ROUXEL, J.; MUNSCHY, C.; AMINOT, Y.; CHOUVELON, T.; MAHE, K.; BUDZINSKI, Hélène; MAUFFRET, A.

doi:10.1016/j.marpolbul.2021.112610

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Marine Pollution Bulletin. 2021-06-17, vol. 170

Resumen en inglés

Telomeres protect the coding sequence of chromosome ends and Telomere Length (TL) has been proposed as a biomarker of cellular aging, cumulative stress exposure and life-span in humans. With the aim to propose new biomarkers, a q-PCR protocol was adapted for the measurement of TL in the European flounder Platichthys flesus. The protocol was then applied in 2-year-old flounders from the Seine Estuary. The absolute TL in the flounder is 54 ± 13 kbp per genome (mean ± standard error). Considering relative or absolute TL, no correlation was observed with DNA damage and any of the measured contaminant concentrations (trace elements, metabolites of polycyclic aromatic hydrocarbons, polychlorobiphenyls, organochlorinated pesticides, polybrominated diphenyl ethers, perfluoroalkyl substances). Because sampling was limited, further investigations are required to state a possible impact of chemical pollution on flatfish telomeres. This is motivated by correlations observed with organochlorinated compounds when decreasing statistical significance (p ≤ 0.10). © 2021 Elsevier Ltd< Leer menos

Palabras clave en inglés

Flatfish

Pollution

Biomonitoring

Telomere

Genotoxicity

DNA damage

URI

https://oskar-bordeaux.fr/handle/20.500.12278/186687

DOI

http://dx.doi.org/10.1016/j.marpolbul.2021.112610

Centros de investigación

EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805

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Development in the European flounder (Platichthys flesus) of a q-PCR assay for the measurement of telomere length, a potential biomarker of pollutant effects for biomonitoring studies

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Resumen en inglés

Palabras clave en inglés

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DOI

Centros de investigación