| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARIANI, Yamuna | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COVELO, Ana | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | RODRIGUES, Rui | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | JULIO-KALAJZIĆ, Francisca | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | PAGANO ZOTTOLA, Antonio | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| hal.structure.identifier | Università degli studi di Palermo - University of Palermo [UNIPA] | |
| dc.contributor.author | LAVANCO, Gianluca | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | FABRIZIO, Michela | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GISQUET, Doriane | |
| dc.contributor.author | DRAGO, Filippo | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CANNICH, Astrid | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | BAUFRETON, Jerome | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARSICANO, Giovanni | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BELLOCCHIO, Luigi | |
| dc.date.accessioned | 2023-12-12T10:25:26Z | |
| dc.date.available | 2023-12-12T10:25:26Z | |
| dc.date.created | 2023-10 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/186564 | |
| dc.description.abstractEn | Repeated exposure to psychostimulants, such as amphetamine, causes a long-lasting enhancement in the behavioral responses to the drug, called behavioral sensitization. 1 This phenomenon involves several neuronal systems and brain areas, among which the dorsal striatum plays a key role. 2 The endocannabinoid system (ECS) has been proposed to participate in this effect, but the neuronal basis of this interaction has not been investigated. 3 In the CNS, the ECS exerts its functions mainly acting through the cannabinoid type-1 (CB1) receptor, which is highly expressed at terminals of striatal medium spiny neurons (MSNs) belonging to both the direct and indirect pathways. 4 In this study, we show that, although striatal CB1 receptors are not involved in the acute response to amphetamine, the behavioral sensitization and related synaptic changes require the activation of CB1 receptors specifically located at striatopallidal MSNs (indirect pathway). These results highlight a new mechanism of psychostimulant sensitization, a phenomenon that plays a key role in the health-threatening effects of these drugs. | |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | |
| dc.description.statementofresponsibility | Neurocircuitry of endocannabinoid regulation of food intake | |
| dc.language.iso | EN | en_US |
| dc.subject.en | CB(1) receptor | |
| dc.subject.en | Psychostimulants | |
| dc.subject.en | Sensitization | |
| dc.subject.en | Striato-pallidal transmission | |
| dc.title.en | Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization | |
| dc.type | Document de travail - Pré-publication | en_US |
| dc.identifier.doi | 10.1016/j.cub.2023.09.075 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC]/Neurobiologie | en_US |
| dc.identifier.pubmed | 37879332 | en_US |
| dc.description.sponsorshipEurope | Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for thetreatment of schizophrenia and psychotic syndromes | |
| bordeaux.journal | Current Biology - CB | en_US |
| bordeaux.page | 5011-5022 | en_US |
| bordeaux.volume | 33 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 22 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04272298 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.subtype | Prepublication/Preprint | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Biology%20-%20CB&rft.volume=33&rft.issue=22&rft.spage=5011-5022&rft.epage=5011-5022&rft.au=MARIANI,%20Yamuna&COVELO,%20Ana&RODRIGUES,%20Rui&JULIO-KALAJZI%C4%86,%20Francisca&PAGANO%20ZOTTOLA,%20Antonio&rft.genre=preprint | |
