TATE, Ashley E; BOUTELOUP, Vincent; VAN MAURIK, Ingrid S; JEAN, Delphine; MANK, Arenda; SPEH, Andreja; BOILET, Valerie; VAN HARTEN, Argonde; ERIKSDOTTER, Maria; WIMO, Anders; DUFOUIL, Carole; VAN DER FLIER, Wiesje M; JONSSON, Linus

doi:10.1002/alz.13488

BOUTELOUP, Vincent
Bordeaux population health [BPH]

VAN MAURIK, Ingrid S

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Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2023-10-01

Résumé en anglais

INTRODUCTION: Inferring the timeline from mild cognitive impairment (MCI) to severe dementia is pivotal for patients, clinicians, and researchers. Literature is sparse and often contains few patients. We aim to determine the time spent in MCI, mild-, moderate-, severe dementia, and institutionalization until death. METHODS: Multistate modeling with Cox regression was used to obtain the sojourn time. Covariates were age at baseline, sex, amyloid status, and Alzheimer's disease (AD) or other dementia diagnosis. The sample included a register (SveDem) and memory clinics (Amsterdam Dementia Cohort and Memento). RESULTS: Using 80,543 patients, the sojourn time from clinically identified MCI to death across all patient groups ranged from 6.20 (95% confidence interval [CI]: 5.57-6.98) to 10.08 (8.94-12.18) years. DISCUSSION: Generally, sojourn time was inversely associated with older age at baseline, males, and AD diagnosis. The results provide key estimates for researchers and clinicians to estimate prognosis.< Réduire

Mots clés en anglais

Alzheimer's disease

Dementia

Epidemiology

Institutionalization

Mortality

Multi-state modeling

Multistate modeling

Sojourn times

URI

https://oskar-bordeaux.fr/handle/20.500.12278/186558

DOI

http://dx.doi.org/10.1002/alz.13488

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Predicting sojourn times across dementia disease stages, institutionalization, and mortality

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