Enterosignatures define common bacterial guilds in the human gut microbiome
| hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
| dc.contributor.author | FRIOUX, Clémence | |
| hal.structure.identifier | Quadram Institute | |
| dc.contributor.author | ANSORGE, Rebecca | |
| hal.structure.identifier | Quadram Institute | |
| dc.contributor.author | ÖZKURT, Ezgi | |
| hal.structure.identifier | Pleiade, from patterns to models in computational biodiversity and biotechnology [PLEIADE] | |
| hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
| dc.contributor.author | GHASSEMI NEDJAD, Chabname | |
| hal.structure.identifier | Quadram Institute | |
| dc.contributor.author | FRITSCHER, Joachim | |
| hal.structure.identifier | Earlham Institute [Norwich] | |
| dc.contributor.author | QUINCE, Christopher | |
| hal.structure.identifier | Centre for Molecular Medicine Norway [NCMM] | |
| dc.contributor.author | WASZAK, Sebastian | |
| hal.structure.identifier | Quadram Institute | |
| dc.contributor.author | HILDEBRAND, Falk | |
| dc.date.issued | 2023-06 | |
| dc.identifier.issn | 1931-3128 | |
| dc.description.abstractEn | The human gut microbiome composition is generally in a stable dynamic equilibrium, but it can deteriorate into dysbiotic states detrimental to host health. To disentangle the inherent complexity and capture the ecological spectrum of microbiome variability, we used 5,230 gut metagenomes to characterize signatures of bacteria commonly co-occurring, termed enterosignatures (ESs). We find five generalizable ESs dominated by either Bacteroides, Firmicutes, Prevotella, Bifidobacterium, or Escherichia. This model confirms key ecological characteristics known from previous enterotype concepts, while enabling the detection of gradual shifts in community structures.Temporal analysis implies that the Bacteroides-associated ES is “core” in the resilience of westernized gut microbiomes, while combinations with other ESs often complement the functional spectrum. The model reliably detects atypical gut microbiomes correlated with adverse host health conditions and/or the presence of pathobionts. ESs provide an interpretable and generic model that enables an intuitive characterization of gut microbiome composition in health and disease. | |
| dc.language.iso | en | |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | metagenomics | |
| dc.subject.en | human gut microbiome | |
| dc.subject.en | non-negative matrix factorization | |
| dc.subject.en | dysbiosis | |
| dc.subject.en | enterosignatures | |
| dc.subject.en | enterotypes | |
| dc.title.en | Enterosignatures define common bacterial guilds in the human gut microbiome | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.chom.2023.05.024 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM] | |
| dc.subject.hal | Statistiques [stat]/Machine Learning [stat.ML] | |
| dc.description.sponsorshipEurope | erc-stg-948219 | |
| bordeaux.journal | Cell Host & Microbe | |
| bordeaux.page | 1111 | |
| bordeaux.volume | 31 | |
| bordeaux.issue | 7 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-04141300 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-04141300v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Host%20&%20Microbe&rft.date=2023-06&rft.volume=31&rft.issue=7&rft.spage=1111&rft.epage=1111&rft.eissn=1931-3128&rft.issn=1931-3128&rft.au=FRIOUX,%20Cl%C3%A9mence&ANSORGE,%20Rebecca&%C3%96ZKURT,%20Ezgi&GHASSEMI%20NEDJAD,%20Chabname&FRITSCHER,%20Joachim&rft.genre=article |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||