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hal.structure.identifierPlateforme Exploration du Métabolisme [PFEM]
dc.contributor.authorHAJJAR, Ghina
hal.structure.identifierPlateforme Bordeaux Metabolome
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBARROS SANTOS, Millena Cristina
hal.structure.identifierInstitut des Maladies Métaboliques et Casdiovasculaires [UPS/Inserm U1297 - I2MC]
dc.contributor.authorBERTRAND-MICHEL, Justine
hal.structure.identifierMetatoul AXIOM [E20]
dc.contributor.authorCANLET, Cécile
hal.structure.identifierMetaboHUB-IDF
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
hal.structure.identifierService de Pharmacologie et Immunoanalyse [SPI]
hal.structure.identifierCEA- Saclay [CEA]
hal.structure.identifierUniversité Paris-Saclay
hal.structure.identifierLaboratoire Innovations en Spectrométrie de Masse pour la santé [LI-MS]
hal.structure.identifierSmall molecule analysis and omics [SMART-OMICS]
dc.contributor.authorCASTELLI, Florence
hal.structure.identifierPlateforme Bordeaux Metabolome
hal.structure.identifierEcosystèmes aquatiques et changements globaux [UR EABX]
dc.contributor.authorCREUSOT, Nicolas
hal.structure.identifierMetaboHUB-IDF
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
dc.contributor.authorDECHAUMET, Sylvain
hal.structure.identifierPlateforme Exploration du Métabolisme [PFEM]
dc.contributor.authorDIÉMÉ, Binta
hal.structure.identifierUnité de Nutrition Humaine [UNH]
dc.contributor.authorGIACOMONI, Franck
hal.structure.identifierMagnetic resonance, Isotopomics, Metabolomics, Monitoring [MIMM]
dc.contributor.authorGIRAUDEAU, Patrick
hal.structure.identifierLaboratoire d'étude des Résidus et Contaminants dans les Aliments [LABERCA]
hal.structure.identifierPlateforme Metabolomics, Lipidomics and Steroidomics Analysis [MELISA]
dc.contributor.authorGUITTON, Yann
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
hal.structure.identifierMetaboHUB-IDF
dc.contributor.authorTHÉVENOT, Etienne A
hal.structure.identifierMetatoul AXIOM [E20]
dc.contributor.authorTREMBLAY-FRANCO, Marie
hal.structure.identifierMetaboHUB-IDF
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
dc.contributor.authorJUNOT, Christophe
hal.structure.identifierMétabolisme et Xénobiotiques [ToxAlim-MeX]
dc.contributor.authorJOURDAN, Fabien
hal.structure.identifierMetaboHUB-IDF
hal.structure.identifierMédicaments et Technologies pour la Santé [MTS]
dc.contributor.authorFENAILLE, François
hal.structure.identifierPlateforme Exploration du Métabolisme [PFEM]
dc.contributor.authorCOMTE, Blandine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
hal.structure.identifierPlateforme Bordeaux Metabolome
dc.contributor.authorPÉTRIACQ, Pierre
hal.structure.identifierPlateforme Exploration du Métabolisme [PFEM]
dc.contributor.authorPUJOS-GUILLOT, Estelle
dc.date.issued2023
dc.identifier.issn0165-9936
dc.description.abstractEnMetabolomics is now a mature phenotyping tool that provides substantial results within various scientific communities. Its application at large-scale, i.e. on large populations and/or samples, has shown its power for research activities from plant science to human epidemiology and medicine, but it still needs key methodological developments for its routine application. Here, we review the current state of large-scale metabolomics applications, providing recent examples of large cohort studies in human and plant/environment research, and present the remaining scientific challenges of both fields. Then, we address the key common methodological issues, from analytics to data science, to fulfil these objectives and go towards a more comprehensive and interoperable large-scale metabolomics, making it a new key actor in the frame of the One-Health future research.
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation
dc.description.sponsorshipCentre français de phénomique végétale - ANR-11-INBS-0012
dc.language.isoen
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/
dc.subject.enCohort
dc.subject.enData science
dc.subject.enInteroperability
dc.subject.enLarge-scale
dc.subject.enMass spectrometry
dc.subject.enMetabolomics
dc.subject.enNuclear magnetic resonance
dc.subject.enOne-health
dc.title.enScaling-up metabolomics: Current state and perspectives
dc.typeArticle de revue
dc.typeArticle de synthèse
dc.identifier.doi10.1016/j.trac.2023.117225
dc.subject.halChimie/Chimie analytique
dc.subject.halSciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]
dc.subject.halSciences du Vivant [q-bio]/Biologie végétale
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie
dc.description.sponsorshipEuropesummit
bordeaux.journalTrends in Analytical Chemistry
bordeaux.page117225
bordeaux.volume167
bordeaux.issue20
bordeaux.peerReviewedoui
hal.identifierhal-04188505
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04188505v1
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