Retroviral DNA Integration.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | LESBATS, Paul | |
| dc.contributor.author | ENGELMAN, Alan N | |
| hal.structure.identifier | Imperial College London | |
| hal.structure.identifier | The Francis Crick Institute [London] | |
| dc.contributor.author | CHEREPANOV, Peter | |
| dc.date.accessioned | 2023-11-16T12:35:11Z | |
| dc.date.available | 2023-11-16T12:35:11Z | |
| dc.date.issued | 2016-10-26 | |
| dc.identifier.issn | 1520-6890 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184811 | |
| dc.description.abstractEn | The integration of a DNA copy of the viral RNA genome into host chromatin is the defining step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded integrase protein, which is conserved among retroviruses and LTR-retrotransposons. Retroviral integration proceeds via two integrase activities: 3'-processing of the viral DNA ends, followed by the strand transfer of the processed ends into host cell chromosomal DNA. Herein we review the molecular mechanism of retroviral DNA integration, with an emphasis on reaction chemistries and architectures of the nucleoprotein complexes involved. We additionally discuss the latest advances on anti-integrase drug development for the treatment of AIDS and the utility of integrating retroviral vectors in gene therapy applications. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | DNA Repair | |
| dc.subject.en | DNA | |
| dc.subject.en | Viral | |
| dc.subject.en | Drug Design | |
| dc.subject.en | HIV Integrase | |
| dc.subject.en | HIV Integrase Inhibitors | |
| dc.subject.en | HIV-1 | |
| dc.subject.en | Protein Conformation | |
| dc.subject.en | Virus Integration | |
| dc.title.en | Retroviral DNA Integration. | |
| dc.title.alternative | Chem Rev | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1128/mmbr.63.4.836-843.1999 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 27198982 | en_US |
| bordeaux.journal | Chemical Reviews | en_US |
| bordeaux.page | 12730-12757 | en_US |
| bordeaux.volume | 116 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 20 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04289297 | |
| hal.version | 1 | |
| hal.date.transferred | 2023-11-16T12:35:15Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chemical%20Reviews&rft.date=2016-10-26&rft.volume=116&rft.issue=20&rft.spage=12730-12757&rft.epage=12730-12757&rft.eissn=1520-6890&rft.issn=1520-6890&rft.au=LESBATS,%20Paul&ENGELMAN,%20Alan%20N&CHEREPANOV,%20Peter&rft.genre=article |
