DESCLIDES, Manon; OZENNE, Valery; BOUR, Pierre; FALLER, Thibaut; MACHINET, Guillaume; PIERRE, Christophe; CHEMOUNY, Stéphane; QUESSON, Bruno

doi:10.1038/s41598-023-29818-z

DESCLIDES, Manon
Centre de résonance magnétique des systèmes biologiques [CRMSB]

OZENNE, Valery

Centre de résonance magnétique des systèmes biologiques [CRMSB]

BOUR, Pierre

Langue

Article de revue

Ce document a été publié dans

Scientific Reports. 2023-02-25, vol. 13, n° 1, p. 3279

Résumé en anglais

Precise control of tissue temperature during Laser-Induced Thermotherapy (LITT) procedures has the potential to improve the clinical efficiency and safety of such minimally invasive therapies. We present a method to automatically regulate in vivo the temperature increase during LITT using real-time rapid volumetric Magnetic Resonance thermometry (8 slices acquired every second, with an in-plane resolution of 1.4 mmx1.4 mm and a slice thickness of 3 mm) using the proton-resonance frequency (PRF) shift technique. The laser output power is adjusted every second using a feedback control algorithm (proportional-integral-derivative controller) to force maximal tissue temperature in the targeted region to follow a predefined temperature-time profile. The root-mean-square of the difference between the target temperature and the measured temperature ranged between 0.5 °C and 1.4 °C, for temperature increases between + 5 °C to + 30 °C above body temperature and a long heating duration (up to 15 min), showing excellent accuracy and stability of the method. These results were obtained on a 1.5 T clinical MRI scanner, showing a potential immediate clinical application of such a temperature controller during MR-guided LITT.< Réduire

Mots clés en anglais

Cancer

Surgical oncology

Biomedical engineering

Imaging techniques

Biological physics

URI

https://oskar-bordeaux.fr/handle/20.500.12278/184808

DOI

http://dx.doi.org/10.1038/s41598-023-29818-z

Project ANR

Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
Thermometrie cardiaque haute résolution sur une IRM clinique en utilisant des antennes intracardiaques - ANR-19-CE19-0008

Unités de recherche

Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536

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Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT)