A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging.
dc.rights.license | open | en_US |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | BOUDRIES, Dahmane | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | MASSOT, Philippe | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | PARZY, Elodie | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | SEREN, Seda | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | MELLET, Philippe | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | FRANCONI, Jean-Michel | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | MIRAUX, Sylvain | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | BEZANÇON, Eric | |
dc.contributor.author | MARQUE, Sylvain R A | |
dc.contributor.author | AUDRAN, Gérard | |
dc.contributor.author | MUETZEL, Markus | |
dc.contributor.author | WINTZHEIMER, Stefan | |
dc.contributor.author | FIDLER, Florian | |
hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
dc.contributor.author | THIAUDIERE, Eric | |
dc.date.accessioned | 2023-11-15T16:52:42Z | |
dc.date.available | 2023-11-15T16:52:42Z | |
dc.date.issued | 2023-03-01 | |
dc.identifier.issn | 1096-0856 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/184778 | |
dc.description.abstractEn | Development of very-low field MRI is an active area of research. It aims at reducing operating costs and improve portability. However, the signal-to-noise issue becomes prominent at ultra-low field (<1 mT), especially for molecular imaging purposes that addresses specific biochemical events. In the context of preclinical molecular MRI of abnormal proteolysis the paper describes a MRI system able to produce Overhauser-enhanced MR images in living rats through in situ Dynamic Nuclear Polarization at 206 µT using stable and non-toxic nitroxides. In parallel conventional images are generated at 206 µT following pre-polarization at 20 mT. Results show that nitroxides are visualized in 3D within a few minutes in the lungs, kidneys and bladder post-administration. This system will be used for molecular imaging of inflammation using protease-specific nitroxide probes. | |
dc.language.iso | EN | en_US |
dc.subject.en | Rats | |
dc.subject.en | Animals | |
dc.subject.en | Magnetic Resonance Spectroscopy | |
dc.subject.en | Magnetic Resonance Imaging | |
dc.subject.en | Lung | |
dc.subject.en | Nitrogen Oxides | |
dc.title.en | A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging. | |
dc.title.alternative | J Magn Reson | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.jmr.2023.107383 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
dc.subject.hal | Sciences de l'ingénieur [physics] | en_US |
dc.identifier.pubmed | 36724576 | en_US |
bordeaux.journal | Journal of Magnetic Resonance | en_US |
bordeaux.page | 107383 | en_US |
bordeaux.volume | 348 | en_US |
bordeaux.hal.laboratories | Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.import.source | pubmed | |
hal.identifier | hal-04287932 | |
hal.version | 1 | |
hal.date.transferred | 2023-11-15T16:52:45Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
workflow.import.source | pubmed | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Magnetic%20Resonance&rft.date=2023-03-01&rft.volume=348&rft.spage=107383&rft.epage=107383&rft.eissn=1096-0856&rft.issn=1096-0856&rft.au=BOUDRIES,%20Dahmane&MASSOT,%20Philippe&PARZY,%20Elodie&SEREN,%20Seda&MELLET,%20Philippe&rft.genre=article |
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