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dc.rights.licenseopenen_US
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorMETIFIOT, Mathieu
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorAMRANE, Samir
hal.structure.identifierInstitut Européen de Chimie et Biologie [IECB]
dc.contributor.authorMERGNY, Jean-Louis
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorANDREOLA, Marie-Line
dc.date.accessioned2023-11-13T11:42:53Z
dc.date.available2023-11-13T11:42:53Z
dc.date.issued2015-11-01
dc.identifier.issn1638-6183en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/184726
dc.description.abstractEnDuring clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trials as anticancer agent. Here, we show that AS1411 exhibits extremely potent antiviral activity and is therefore an attractive new lead as anti-HIV agent.
dc.language.isoENen_US
dc.subject.enAnti-HIV Agents
dc.subject.enAntineoplastic Agents
dc.subject.enAptamers
dc.subject.enNucleotide
dc.subject.enCell Line
dc.subject.enCell Proliferation
dc.subject.enHIV-1
dc.subject.enHumans
dc.subject.enOligodeoxyribonucleotides
dc.title.enAnticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1.
dc.title.alternativeBiochimieen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.biochi.2015.09.009en_US
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologieen_US
dc.identifier.pubmed26363100en_US
bordeaux.journalBiochimieen_US
bordeaux.page173-5en_US
bordeaux.volume118en_US
bordeaux.hal.laboratoriesMFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234en_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04282124
hal.version1
hal.date.transferred2023-11-13T11:42:55Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biochimie&rft.date=2015-11-01&rft.volume=118&rft.spage=173-5&rft.epage=173-5&rft.eissn=1638-6183&rft.issn=1638-6183&rft.au=METIFIOT,%20Mathieu&AMRANE,%20Samir&MERGNY,%20Jean-Louis&ANDREOLA,%20Marie-Line&rft.genre=article


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