DURAND, Pauline; POTTIER, Valérie; MESGUICH, Charles; DEBORDEAUX, Frédéric; LAZARO, Estibaliz; VIALLARD, Jean-François; RIVIÈRE, Etienne

Langue

Article de revue

Ce document a été publié dans

Experimental Hematology & Oncology. 2023-05-30, vol. 12, n° 1, p. 50

Résumé en anglais

Thrombocytopenia occurs in 60% of patients with myelodysplastic syndromes (MDS), increasing the risk of life-threatening haemorrhage in this population of mainly old patients with comorbidities. However, data are scare regarding immune thrombocytopenia (ITP) secondary to MDS. We analyzed the utility of indium-111 platelet scintigraphy (IPS) to better characterize the mechanisms of thrombocytopenia in 21 adult patients with MDS. Adult patients with a definite diagnosis of MDS according to the international criteria who underwent IPS between 2009 and 2018 because of an increased bleeding risk were retrospectively selected. Autologous 111Indium platelet labelling was performed with a technique similar to that described previously using a standardized method. Platelet lifespan ≤ 6 days identified patients with peripheral platelet destruction. Taking into account the response to ITP-directed therapies after IPS, the sensitivity, specificity, and positive and negative predictive values of IPS were 100%, 84.6%, 80%, and 100%, respectively. We show that IPS can be a useful tool to identify the mechanism and guide treatment of a chronic thrombocytopenia increasing the bleeding risk in patients with MDS.< Réduire

Mots clés

Article clinique

Mots clés en anglais

Immune thrombocytopenia

Indium-111 platelet scintigraphy

Myelodysplastic syndrome

URI

https://oskar-bordeaux.fr/handle/20.500.12278/183411

Voir/Ouvrir

Métadonnées

Licence d’utilisation du document

Utility of indium-111 platelet scintigraphy for understanding the mechanism of thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia.

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés

Mots clés en anglais

URI

Unités de recherche

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Utility of indium-111 platelet scintigraphy for understanding the mechanism of thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia.

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés

Mots clés en anglais

URI

Unités de recherche