DUPIRE, C.; CHENNELL, P.; PEREIRA, B.; COURTIOL, N.; BUJ, S.; CUEFF, R.; CRAUSTE-MANCIET, S.; SAUTOU, V.; MORGAT, Clement

doi:10.1038/s41598-023-29923-z

Langue

Article de revue

Ce document a été publié dans

Scientific Reports. 2023-02-15, vol. 13, n° 1, p. 2721

Résumé en anglais

The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a radionuclide enabling quantification and imaging using dedicated scanners. The sorption of nine different radiopharmaceuticals on 2- and 3-part syringes was investigated. These syringes were filled with the studied radiopharmaceutical solutions and stored immobile for 3 h. At different times ranging from 0 to 180 min, 10 µL were taken from the syringes and the radioactivity of these samples was determined by a gamma counter. 5 radiopharmaceuticals exhibited no significant sorption at any time point in both 2 and 3-parts syringes, but 4 radiopharmaceuticals exhibited sorption losses varying from 20 to 33% after 3 h contact with 3-part-syringes, but no sorption on 2-part syringes at any time point. [Tc]Tc-tetrofosmine Single Photon Emission Computed Tomography/Computed Tomography imaging indicated clearly that the interactions were located on the rubber plunger of the 3-part-syringes. The specific nature of radiopharmaceuticals allowed their use as an innovative method to quantify and localize drug sorption phenomena.< Réduire

Mots clés en anglais

Radiopharmaceuticals

Syringes

Rubber

URI

https://oskar-bordeaux.fr/handle/20.500.12278/183231

DOI

http://dx.doi.org/10.1038/s41598-023-29923-z

Unités de recherche

Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche