MARTIN, Anouk; LALANNE, Pierre; VAX, Amélie; MUTSCHLER, Angela; LECOMMANDOUX, Sebastien

doi:10.1016/j.ijpharm.2023.123157

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

LALANNE, Pierre

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

VAX, Amélie

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

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Article de revue

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International Journal of Pharmaceutics. 2023-06-20, vol. 642, p. 123157

Résumé en anglais

The self-assembly of poly(ethylene glycol)-block-poly(trimethylene carbonate) PEG-b-PTMC copolymers into vesicles, also referred as polymersomes, was evaluated by solvent displacement using microfluidic systems. Two microfluidic chips with different flow regimes (micromixer and Herringbone) were used and the impact of process conditions on vesicle formation was evaluated. As polymersomes are sensitive to osmotic variations, their preparation under conditions allowing their direct use in biological medium is of major importance. We therefore developed a solvent exchange approach from DMSO (Dimethylsulfoxide) to aqueous media with an osmolarity of 300 mOsm.L-1, allowing their direct use for biological evaluation. We evidenced that the organic/aqueous solvent ratio does not impact vesicle size, but the total flow rate and copolymer concentration have been observed to influence the size of polymersomes. Finally, nanoparticles with diameters ranging from 76 nm to 224 nm were confirmed to be vesicles through the use of multi-angle light scattering in combination with cryo-TEM (Cryo-Transmission Electron Microscopy) characterization.< Réduire

Mots clés en anglais

Microfluidic

polymersomes

size control

self-assembly

nanomedicine

URI

https://oskar-bordeaux.fr/handle/20.500.12278/182756

DOI

http://dx.doi.org/10.1016/j.ijpharm.2023.123157

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Controlling Polymersome Size through Microfluidic-Assisted Self-Assembly: Enabling 'Ready to Use' formulations for biological applications

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Résumé en anglais

Mots clés en anglais

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Unités de recherche